Chelerythrine
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- ₹0
- Product name: Chelerythrine
- CAS: 34316-15-9
- MF: C21H18NO4+
- MW: 348.37192
- EINECS:251-930-0
- MDL Number:MFCD00270393
- Synonyms:1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride;Chelerythrine chloride;CHELERYTHRINE(TODDALINE)(RG);1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium ;chelerythrine/toddaline;1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium;Cheleritrine
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Properties
Melting point :195-205°C
Boiling point :496.37°C (rough estimate)
Density :1.2985 (rough estimate)
refractive index :1.5614 (estimate)
storage temp. :Desiccate at -20°C
solubility :Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly）
form :Solid
color :Light Yellow to Dark Orange
Stability :Hygroscopic
LogP :-0.401 (est)
CAS DataBase Reference :34316-15-9(CAS DataBase Reference)
Boiling point :496.37°C (rough estimate)
Density :1.2985 (rough estimate)
refractive index :1.5614 (estimate)
storage temp. :Desiccate at -20°C
solubility :Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly）
form :Solid
color :Light Yellow to Dark Orange
Stability :Hygroscopic
LogP :-0.401 (est)
CAS DataBase Reference :34316-15-9(CAS DataBase Reference)
Safety Information
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Description
Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad.Related product price
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