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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Forensic and veterinary standards >Chlortalidone

Chlortalidone

Chlortalidone Structure
  • ₹6235.2 - ₹25352.15
  • Product name: Chlortalidone
  • CAS: 77-36-1
  • MF: C14H11ClN2O4S
  • MW: 338.77
  • EINECS:201-022-5
  • MDL Number:MFCD00036257
  • Synonyms:thalitone;2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1h-isoindol-1-yl)benzenesulfonamide;hygroton;CHLORTHALIDONE;CHLORTALIDONE;1-keto-3-(3’-sulfamyl-4’-chlorophenyl)-3-hydroxyisoindoline ;1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline ;2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-benzenesulfonamid
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0591
  • Product descriptionChlorthalidone ≥98% (HPLC)
  • Packaging5MG
  • Price₹6235.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0591
  • Product descriptionChlorthalidone ≥98% (HPLC)
  • Packaging25MG
  • Price₹25352.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0591 Chlorthalidone ≥98% (HPLC) 5MG ₹6235.2 2022-06-14 Buy
Sigma-Aldrich(India) SML0591 Chlorthalidone ≥98% (HPLC) 25MG ₹25352.15 2022-06-14 Buy

Properties

Melting point :265-267°C (dec.)
Density :1.3356 (rough estimate)
refractive index :1.5630 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :pKa 9.4 (Uncertain)
form :powder
color :white to beige
Water Solubility :0.12g/L(25 ºC)
Stability :Hygroscopic
InChIKey :JIVPVXMEBJLZRO-UHFFFAOYSA-N
NIST Chemistry Reference :Chlorthalidone(77-36-1)
EPA Substance Registry System :Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)- (77-36-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Chlorthalidone is a nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC50s = 2.8 nM - 11 μM), which has been attributed to the sustained vasodilator capability of this compound. Chlorthalidone has been used independently or in combination with other antihypertensive agents to lower arterial blood pressure, and also as an adjuvant to address edema caused by cardiac or renal disorders.

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Suppliers and manufacturers

SURYA LIFE SCIENCES LIMITED SKVen Technologies Pvt.Ltd. PRODIGIOUS LIFE SCIENCES KARPSCHEM LABORATORIES Honour Lab Limited Ipca Laboratories Ltd CTX Lifesciences Pvt Ltd Unichem Laboratories Ltd ENANTI LABS PVT LTD Vanquest Pharma Pvt Ltd