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Cyproheptadine

Cyproheptadine Structure
  • ₹0
  • Product name: Cyproheptadine
  • CAS: 129-03-3
  • MF: C21H21N
  • MW: 287.4
  • EINECS:204-928-9
  • MDL Number:MFCD00242817
  • Synonyms:1-Methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine;Cypoheptadine;Cyproheptadiene;Dronactin;Eiproheptadine;MK 141;Periactine;Periactinol
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :112.3-113.3°
Boiling point :419.7°C (rough estimate)
Density :0.9917 (rough estimate)
refractive index :1.8240 (estimate)
storage temp. :Store at -20°C
form :Solid
pka :pKa 8.87 (Uncertain)
color :Crystals from EtOH (aq)
Water Solubility :317.6ug/L(22.5 ºC)
CAS DataBase Reference :129-03-3(CAS DataBase Reference)
NIST Chemistry Reference :Cyproheptadine(129-03-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cyproheptadine is a first-generation antihistamine that potently antagonizes the histamine H1 receptor (pKi = 9.42). It also antagonizes serotonin and muscarinic receptors at nanomolar concentrations. Cyproheptadine also inhibits the lysine methyltransferase SET7/9 (IC50 = 1 μM), suppressing the expression of estrogen receptor α in human breast cancer MCF-7 cells.

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