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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Glycine derivative >DL-THIORPHAN

DL-THIORPHAN

DL-THIORPHAN Structure
  • ₹17991.15 - ₹71369.23
  • Product name: DL-THIORPHAN
  • CAS: 76721-89-6
  • MF: C12H15NO3S
  • MW: 253.32
  • EINECS:
  • MDL Number:MFCD00058435
  • Synonyms:N-[(RS)-2-BENZYL-3-MERCAPTOPROPANOYL]-GLYCINE;(+/-)-N-(3-MERCAPTO-2-BENZYLPROPIONYL)GLYCINE;N-ALPHA-(DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLYCINE;THIORPHAN;THIORPHAN (DL);((RS)-2-BENZYL-3-MERCAPTOPROPIONYL)-GLYCINE;((RS)-2-BENZYL-3-MERCAPTOPROPIONYL)-GLY-OH;2-Mercaptomethyl-3-phenyl-propionylamino-acetic Acid, D,L-3-Mercapto-2-benzylpropanoylglycine,
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberT6031
  • Product descriptionDL-Thiorphan ≥98% (TLC)
  • Packaging25MG
  • Price₹71369.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number598510
  • Product descriptionDL-Thiorphan - CAS 76721-89-6 - Calbiochem A thiol containing amido-acid that selectively binds to the active site zinc of metalloproteinases and blocks their activity (IC?? = 2.1 nM for neutra
  • Packaging10MG
  • Price₹39430
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT6031
  • Product descriptionDL-Thiorphan ≥98% (TLC)
  • Packaging5MG
  • Price₹17991.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) T6031 DL-Thiorphan ≥98% (TLC) 25MG ₹71369.23 2022-06-14 Buy
Sigma-Aldrich(India) 598510 DL-Thiorphan - CAS 76721-89-6 - Calbiochem A thiol containing amido-acid that selectively binds to the active site zinc of metalloproteinases and blocks their activity (IC?? = 2.1 nM for neutra 10MG ₹39430 2022-06-14 Buy
Sigma-Aldrich(India) T6031 DL-Thiorphan ≥98% (TLC) 5MG ₹17991.15 2022-06-14 Buy

Properties

Melting point :138-140 °C
Boiling point :524.0±50.0 °C(Predicted)
Density :1.246±0.06 g/cm3(Predicted)
RTECS :MC0596440
storage temp. :-15°C
solubility :ethanol: 50 mg/mL, clear, colorless
form :White solid
pka :3.48±0.10(Predicted)
color :White to Off-White
BRN :4872101
CAS DataBase Reference :76721-89-6

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Thiorphan is a potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM). It is much less effective against neprilysin-2 (IC50 = 22.1 μM), angiotensin-converting enzyme, and endothelin-converting enzyme-1. Thiorphan can be produced in vivo via the metabolism of the prodrug acetorphan. Neprilysin is overexpressed in many forms of cancer and may play a role in protecting against Alzheimer’s disease.

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