Debromo Hymenialdisine
|
- ₹0
- Product name: Debromo Hymenialdisine
- CAS: 75593-17-8
- MF: C11H10N5O2
- MW: 244.2294
- EINECS:
- MDL Number:MFCD04037016
- Synonyms:DEBROMOHYMENIALDISINE;Debromohymenialdesine;Pyrrolo[2,3-c]azepin-8(1H)-one, 4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-, (4Z)-
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|
Properties
Melting point :>250°C (dec.)
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :DMSO, Methanol
form :Yellow solid.
color :Yellow
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :DMSO, Methanol
form :Yellow solid.
color :Yellow
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2. Debromohymenialdisine (DBH) is a marine sponge alkaloid that inhibits Chk1 and Chk2 (IC50 = 3 and 3.5 μM, respectively), blocking G2 arrest. Because it does not significantly affect the activity of ataxia-telangiectasia mutated (ATM) or ATM-Tad2-related protein, DBH is a useful tool for studying the roles of Chk1 and Chk2 in DNA repair and cell cycle regulation. DBH also inhibits MAP kinase kinase 1 (IC50 = 881 nM), glycogen synthase kinase 3β (IC50 = 1.39 μM), cyclin-dependent kinase 5/p25 (IC50 = 9.12 μM), protein tyrosine kinase 6 (IC50 = 0.6 μM), and other kinases largely unrelated to DNA damage/repair and cell cycling.More related product prices
CHK2 INHIBITOR IIRelated product price
- CHK2 INHIBITOR II
₹19701.5-75244.58