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CHK2 INHIBITOR II

CHK2 INHIBITOR II Structure
  • ₹19701.5 - ₹75244.58
  • Product name: CHK2 INHIBITOR II
  • CAS: 516480-79-8
  • MF: C20H14ClN3O2
  • MW: 363.8
  • EINECS:
  • MDL Number:MFCD08276917
  • Synonyms:C 3742;BML-277;2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE;2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxylic acid amide;C 3742 BML-277;InSolution? Chk2 Inhibitor II ;2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide;2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3742
  • Product descriptionChk2 Inhibitor II hydrate ≥98% (HPLC)
  • Packaging5MG
  • Price₹19701.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number220491
  • Product descriptionInSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem The InSolution Chk2 Inhibitor II, also referenced under CAS 516480-79-8, controls the biological activity of Chk2. This small molecule/inhibitor is pr
  • Packaging5MG
  • Price₹20250
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3742
  • Product descriptionChk2 Inhibitor II hydrate ≥98% (HPLC)
  • Packaging25MG
  • Price₹75244.58
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C3742 Chk2 Inhibitor II hydrate ≥98% (HPLC) 5MG ₹19701.5 2022-06-14 Buy
Sigma-Aldrich(India) 220491 InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem The InSolution Chk2 Inhibitor II, also referenced under CAS 516480-79-8, controls the biological activity of Chk2. This small molecule/inhibitor is pr 5MG ₹20250 2022-06-14 Buy
Sigma-Aldrich(India) C3742 Chk2 Inhibitor II hydrate ≥98% (HPLC) 25MG ₹75244.58 2022-06-14 Buy

Properties

Boiling point :637.1±63.0 °C(Predicted)
Density :1.390±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 18 mg/mL
form :solid
pka :10.40±0.10(Predicted)
color :tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.

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