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ChemicalBook > Product Catalogue >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >Diclofenac potassium

Diclofenac potassium

Diclofenac potassium Structure
  • ₹23760.88
  • Product name: Diclofenac potassium
  • CAS: 15307-81-0
  • MF: C14H10Cl2KNO2
  • MW: 334.24
  • EINECS:630-422-6
  • MDL Number:MFCD00082254
  • Synonyms:ProSorb;potassium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate;Diclofenic potassiuM;Benzeneaceticacid, 2-[(2,6-dichlorophenyl)aMino]-, potassiuM salt (1:1);POTASSIUM [2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETATE;DICLOFENAC POTASSIUM;DICLOFENAC POTASSIUM SALT;2[(2,6-dichlorophenyl)amino]benzeneacetic acid potassium salt
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Brand

  • Sigma-Aldrich(India)

Package

  • 500MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2441
  • Product descriptionDiclofenac potassium Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹23760.88
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PHR2441 Diclofenac potassium Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹23760.88 2022-06-14 Buy

Properties

Melting point :300-330 °C
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :Sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96 per cent), slightly soluble in acetone.
form :Solid
color :White to off-white
CAS DataBase Reference :15307-81-0(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:

Description

Dichlofenac potassium is the potassium salt of dichlofenac. It is a nonsteroidal anti-inflammatory agent that can be used to reduce inflammation and as an analgesic to reduce pain in certain conditions. It can also used to treat dysmenorrhea. It can treat inflammatory disorders such as musculoskeletal complaints, dental pain, arthritis, actinic keratosis, joint pain, acute pain and chronic pain caused by certain kinds of cancers. Traditional opinion proposes that diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. However, recent studies have shown that the pharmacologic activity of diclofenac goes beyond COX inhibition, and includes multimodal and, in some instances, novel mechanisms of action (MOA). For example, research suggests diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide–cGMP antinociceptive pathway. Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARγ), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia.

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