Welcome to chemicalbook!
China english Japan Germany India
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
head sculpture My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook > Product Catalogue >API >Circulatory system drugs >Antiarrhythmics Drugs >Dofetilide

Dofetilide

Dofetilide Structure
  • ₹15891.1 - ₹63477.8
  • Product name: Dofetilide
  • CAS: 115256-11-6
  • MF: C19H27N3O5S2
  • MW: 441.56
  • EINECS:638-817-5
  • MDL Number:MFCD00869707
  • Synonyms:Tikosyn;beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide;Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl) phenyl);Tikosym;Methyl[2-[4-(methylsulfonylamino)phenoxy]ethyl][4-(methylsulfonylamino)phenethyl]amine;N-[4-[2-[N-Methyl-2-(4-methylsulfonylaminophenoxy)ethylamino]ethyl]phenyl]methanesulfonamide;U-68798;N-[4-[2-[2-[4-(methanesulfonamido)phenyl]ethyl-methylamino]ethoxy]phenyl]methanesulfonamide
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0016
  • Product descriptionDofetilide ≥98% (HPLC)
  • Packaging5MG
  • Price₹15891.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0016
  • Product descriptionDofetilide ≥98% (HPLC)
  • Packaging25MG
  • Price₹63477.8
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0016 Dofetilide ≥98% (HPLC) 5MG ₹15891.1 2022-06-14 Buy
Sigma-Aldrich(India) PZ0016 Dofetilide ≥98% (HPLC) 25MG ₹63477.8 2022-06-14 Buy

Properties

Melting point :147-1490C
Boiling point :614.1±65.0 °C(Predicted)
Density :1.344±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
pka :7.0, 9.0, 9.6(at 25℃)
form :powder
color :white to off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :IXTMWRCNAAVVAI-UHFFFAOYSA-N
CAS DataBase Reference :115256-11-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 μM dofetilide demonstrates pro-arrhythmic activity, inducing early after depolarizations (prolonged repolarization) in cell models and Torsade de Pointes in animal models. Given this adverse side effect, dofetilide has been cautiously used in the treatment of atrial fibrillation, the conversion of flutter to sinus rhythm, and in the maintenance of sinus rhythm after conversion.

More related product prices

3-Aminobenzenesulfonamide Trinexapac-ethyl Etanol Ethyl acetate Diphenyl oxide Phenyl salicylate Diphenyldimethoxysilane 4-Methoxyphenylacetone Benzenesulfonamide Ethylparaben Sulfanilamide Phenylacetic acid Phenanthrene Methanesulfonamide Dofetilide

Related product price

Suppliers and manufacturers

Honour Lab Limited Biophore India Pharmaceuticals Pvt Ltd Apicore Pharmaceuticals Pvt Ltd Enaltec Labs Pvt Ltd CLEANCHEM LABORATORIES LLP KPS Chemicals & Pharmaceuticals EMCURE PHARMACEUTICALS LTD SUN PHARMACEUTICAL INDUSTRIES LTD AUROBINDO PHARMA LTD MSN LIFE SCIENCES PRIVATE LTD