Efavirenz
- ₹15403.98 - ₹62633.45
- Product name: Efavirenz
- CAS: 154598-52-4
- MF: C14H9ClF3NO2
- MW: 315.67
- EINECS:620-492-6
- MDL Number:MFCD05662344
- Synonyms:(S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl) 2H-3,1-benzoxazin-2-one;(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one;Efavirenz (200 mg);(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoroMethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoroMethyl)-, (4S)-;efavuirenz;Efavirenz solution;(S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-4-(TRIFLUOROMETHYL)-1H-BENZO[D][1,3]OXAZIN-2(4H)-ONE
4 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- 500MG
- 1ML
- ManufacturerSigma-Aldrich(India)
- Product numberSML0536
- Product descriptionEfavirenz ≥98% (HPLC)
- Packaging10MG
- Price₹15403.98
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1284
- Product descriptionEfavirenz Ready Made Solution 10?mg/mL in DMSO
- Packaging1ML
- Price₹17236.8
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPHR2072
- Product descriptionEfavirenz Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging500MG
- Price₹29996.08
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0536
- Product descriptionEfavirenz ≥98% (HPLC)
- Packaging50MG
- Price₹62633.45
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML0536 | Efavirenz ≥98% (HPLC) | 10MG | ₹15403.98 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1284 | Efavirenz Ready Made Solution 10?mg/mL in DMSO | 1ML | ₹17236.8 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PHR2072 | Efavirenz Pharmaceutical Secondary Standard; Certified Reference Material | 500MG | ₹29996.08 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0536 | Efavirenz ≥98% (HPLC) | 50MG | ₹62633.45 | 2022-06-14 | Buy |
Properties
Melting point :139-141°C
Boiling point :340.6±42.0 °C(Predicted)
alpha :D20 -84.7° (c = 0.005 g/ml in CH3Cl); D25 -94.1° (c = 0.300 in methanol)
Density :1.53±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
pka :10.2(at 25℃)
form :powder or crystals
color :white to beige
optical activity :[α]/D -90 to -100°, c = 1 in methanol
Water Solubility :8mg/L(temperature not stated)
λmax :247nm(MeOH)(lit.)
Merck :14,3521
BCS Class :4
EPA Substance Registry System :2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)- (154598-52-4)
Boiling point :340.6±42.0 °C(Predicted)
alpha :D20 -84.7° (c = 0.005 g/ml in CH3Cl); D25 -94.1° (c = 0.300 in methanol)
Density :1.53±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
pka :10.2(at 25℃)
form :powder or crystals
color :white to beige
optical activity :[α]/D -90 to -100°, c = 1 in methanol
Water Solubility :8mg/L(temperature not stated)
λmax :247nm(MeOH)(lit.)
Merck :14,3521
BCS Class :4
EPA Substance Registry System :2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)- (154598-52-4)
Safety Information
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Description
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Efavirenz is an NNRTI that prevents RNA plus-strand initiation with an IC50 value of 17 nM. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV and cancer.More related product prices
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