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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Transmembrane Transporters >P-gp inhibitors >Elacridar

Elacridar

Elacridar Structure
  • ₹9600 - ₹62038.08
  • Product name: Elacridar
  • CAS: 143664-11-3
  • MF: C34H33N3O5
  • MW: 563.64
  • EINECS:1532714-185-1
  • MDL Number:MFCD00912604
  • Synonyms:elacridar;n-[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10h-acridine-4-carboxamide;GF 120918;GG 918;GW 0918;N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide;N-[4-[2-(3,4-Dihydro-6,7-diMethoxy-isoquinolin-2(1H)-yl)ethyl]phenyl]-9,10-dihydro-5-Methoxy-9-oxo-4-acridinecarboxaMide;1-{2-carbaMoyl-5-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}-5-Methoxy-9-oxo-9,10-dihydroacridine-4-carboxylic acid
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 25MG
  • 50MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberE1371
  • Product descriptionElacridar
  • Packaging25MG
  • Price₹9600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberE1371
  • Product descriptionElacridar
  • Packaging100MG
  • Price₹23100
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0486
  • Product descriptionElacridar ≥98% (HPLC)
  • Packaging10MG
  • Price₹15403.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0486
  • Product descriptionElacridar ≥98% (HPLC)
  • Packaging50MG
  • Price₹62038.08
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) E1371 Elacridar 25MG ₹9600 2022-05-26 Buy
TCI Chemicals (India) E1371 Elacridar 100MG ₹23100 2022-05-26 Buy
Sigma-Aldrich(India) SML0486 Elacridar ≥98% (HPLC) 10MG ₹15403.98 2022-06-14 Buy
Sigma-Aldrich(India) SML0486 Elacridar ≥98% (HPLC) 50MG ₹62038.08 2022-06-14 Buy

Properties

Melting point :216-218°C
Boiling point :701.6±60.0 °C(Predicted)
Density :1.264±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
pka :12.58±0.70(Predicted)
color :white to beige
CAS DataBase Reference :143664-11-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P273 Avoid release to the environment.

Description

Elacridar is a dual inhibitor of P-glycoprotein (MRP-1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2). It maximally inhibits P-glycoprotein in isolated human peripheral blood leukocytes at 200 nM. Elacridar blocks the activity of P-glycoprotein at the blood-brain barrier, altering the pharmacokinetics of certain drugs in the brain. This compound is effective against both human BCRP and the mouse homolog, Bcrp1.

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