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ChemicalBook > Product Catalogue >API >Respiratory Drugs >Asthma drugs >Esculetin

Esculetin

Esculetin Structure
  • ₹2700 - ₹11701.83
  • Product name: Esculetin
  • CAS: 305-01-1
  • MF: C9H6O4
  • MW: 178.14
  • EINECS:206-161-5
  • MDL Number:MFCD00006874
  • Synonyms:CICHORIGENIN;CICHERINGENIN;ESCULETOL;ESCULETIN;LABOTEST-BB LT00233229;AKOS 215-98;6,7-DIHYDROXY-CHROMEN-2-ONE;2H-1-BENZOPYRAN-2-ONE, 6,7-DIHYDROXY-
6 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 50MG
  • 200MG
  • 1G
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberE1287
  • Product descriptionEsculetin [Matrix for MALDI-TOF/MS]
  • Packaging200MG
  • Price₹2700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberE0386
  • Product descriptionEsculetin
  • Packaging1G
  • Price₹3100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberE1287
  • Product descriptionEsculetin [Matrix for MALDI-TOF/MS]
  • Packaging1G
  • Price₹7800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number246573
  • Product description6,7-Dihydroxycoumarin 98%
  • Packaging1G
  • Price₹2749.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number68923
  • Product descriptionEsculetin analytical standard
  • Packaging50MG
  • Price₹5585.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number246573
  • Product description6,7-Dihydroxycoumarin 98%
  • Packaging5G
  • Price₹11701.83
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) E1287 Esculetin [Matrix for MALDI-TOF/MS] 200MG ₹2700 2022-05-26 Buy
TCI Chemicals (India) E0386 Esculetin 1G ₹3100 2022-05-26 Buy
TCI Chemicals (India) E1287 Esculetin [Matrix for MALDI-TOF/MS] 1G ₹7800 2022-05-26 Buy
Sigma-Aldrich(India) 246573 6,7-Dihydroxycoumarin 98% 1G ₹2749.55 2022-06-14 Buy
Sigma-Aldrich(India) 68923 Esculetin analytical standard 50MG ₹5585.7 2022-06-14 Buy
Sigma-Aldrich(India) 246573 6,7-Dihydroxycoumarin 98% 5G ₹11701.83 2022-06-14 Buy

Properties

Melting point :271-273 °C(lit.)
Boiling point :270.35°C (rough estimate)
Density :1.3431 (rough estimate)
refractive index :1.4500 (estimate)
storage temp. :2-8°C
solubility :Solubility Almost insoluble in boiling water, ether; soluble in hot ethanol, glacial acetic acid
form :powder
pka :1.71(at 25℃)
color :Light yellow
PH Range :Weak blue uorescence (1.5) to strong blue uorescence (2.0)
Water Solubility :slightly soluble
Merck :14,3697
BRN :152788
Major Application :antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness
InChIKey :ILEDWLMCKZNDJK-UHFFFAOYSA-N
LogP :0.980 (est)
CAS DataBase Reference :305-01-1(CAS DataBase Reference)
NIST Chemistry Reference :Coumarin, 6,7-dihydroxy-(305-01-1)
EPA Substance Registry System :Esculetin (305-01-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

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