EzetiMibe-d4
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- Product name: EzetiMibe-d4
- CAS: 1093659-89-2
- MF: C24H21F2NO3
- MW: 409.43
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- MDL Number:
- Synonyms:(3R,4S)-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-[(3S)-3-hydroxy-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)propyl]azetidin-2-one;[2H4]-Ezetimibe;Ezetimibe Impurity 119;Ezetimibe D4Q: What is Ezetimibe D4 Q: What is the CAS Number of Ezetimibe D4 Q: What is the storage condition of Ezetimibe D4;Ezetimibe-d4-1;Ezetimibe D4 (4-Fluorophenyl-2,3,5,6-d4)
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Properties
storage temp. :Store at -20°C
solubility :DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form :A solid
color :White to off-white
solubility :DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form :A solid
color :White to off-white
Safety Information
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Description
Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1. Ezetimibe exhibits ED50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.More related product prices
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