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FR 122047 HYDROCHLORIDE

FR 122047 HYDROCHLORIDE Structure
  • ₹20250 - ₹54742.03
  • Product name: FR 122047 HYDROCHLORIDE
  • CAS: 130717-51-0
  • MF: C23H26ClN3O3S
  • MW: 459.99
  • EINECS:
  • MDL Number:MFCD00925604
  • Synonyms:4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL)-2-[(1-METHYLPIPERAZINE-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE;1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;FR 122047;FR 122047 HYDROCHLORIDE;FR122047HCl;(4,5-Bis(4-Methoxyphenyl)thiazol-2-yl)(4-Methylpiperazin-1-yl)Methanone hydrochloride
Price2 Properties Safety Information Description
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number236005
  • Product descriptionCOX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is prim
  • Packaging5MG
  • Price₹20250
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberF7553
  • Product descriptionFR 122047 hydrochloride ≥98% (HPLC), powder
  • Packaging25MG
  • Price₹54742.03
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 236005 COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is prim 5MG ₹20250 2022-06-14 Buy
Sigma-Aldrich(India) F7553 FR 122047 hydrochloride ≥98% (HPLC), powder 25MG ₹54742.03 2022-06-14 Buy

Properties

storage temp. :2-8°C
solubility :methylene chloride: 50 mg/mL, slightly hazy, yellow
form :powder
color :faint yellow
Water Solubility :Soluble to 10 mM in water

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

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