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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >TGF-beta / Smad >PKC inhibitor >GO 6976

GO 6976

GO 6976 Structure
  • ₹22650 - ₹26950
  • Product name: GO 6976
  • CAS: 136194-77-9
  • MF: C24H18N4O
  • MW: 378.43
  • EINECS:200-258-5
  • MDL Number:MFCD00236434
  • Synonyms:InSolution? G? 6976 ;5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile;Go6976,5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile;PD406976;12-(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO(2,3-A)PYRROLO(3,4-C)-CARBAZOLE;12-2(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE;GO 6976;G6976
Price3 Properties Safety Information Description
3 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 500μG
  • 1MG
  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product number365250
  • Product descriptionGö 6976 - CAS 136194-77-9 - Calbiochem G? 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC?? = 7.9 nM for rat brain). Exhibits selectively fo
  • Packaging1MG
  • Price₹22650
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number365253
  • Product descriptionInSolution Gö 6976 - CAS 136194-77-9 - Calbiochem
  • Packaging1ML
  • Price₹25060
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number365250
  • Product descriptionGö 6976 - CAS 136194-77-9 - Calbiochem G? 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC?? = 7.9 nM for rat brain). Exhibits selectively fo
  • Packaging500μG
  • Price₹26950
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 365250 Gö 6976 - CAS 136194-77-9 - Calbiochem G? 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC?? = 7.9 nM for rat brain). Exhibits selectively fo 1MG ₹22650 2022-06-14 Buy
Sigma-Aldrich(India) 365253 InSolution Gö 6976 - CAS 136194-77-9 - Calbiochem 1ML ₹25060 2022-06-14 Buy
Sigma-Aldrich(India) 365250 Gö 6976 - CAS 136194-77-9 - Calbiochem G? 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC?? = 7.9 nM for rat brain). Exhibits selectively fo 500μG ₹26950 2022-06-14 Buy

Properties

Melting point :>221°C (dec.)
Boiling point :652.3±55.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly)
form :Off-white solid
pka :14.39±0.20(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

G? 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively. It does not inhibit the activity of PKCδ, PKCε, or PKCζ (IC50s > 3 μM), indicating a preference for the Ca2+-dependent subtypes, PKCα and PKCβ1. G? 6976 also inhibits the checkpoint kinases Chk1/2. It was shown to abrogate DNA damage-induced S- and G2-phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.

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