GSK 2830371
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- ₹11528.63 - ₹46515.03
- Product name: GSK 2830371
- CAS: 1404456-53-6
- MF: C23H29ClN4O2S
- MW: 461.02
- EINECS:
- MDL Number:MFCD28009442
- Synonyms:GSK 2830371;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide;(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide;GSK 2830371 USP/EP/BP;2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide;GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1048
- Product descriptionGSK2830371 ≥98% (HPLC)
- Packaging5MG
- Price₹11528.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1048
- Product descriptionGSK2830371 ≥98% (HPLC)
- Packaging25MG
- Price₹46515.03
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1048 | GSK2830371 ≥98% (HPLC) | 5MG | ₹11528.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1048 | GSK2830371 ≥98% (HPLC) | 25MG | ₹46515.03 | 2022-06-14 | Buy |
Properties
Boiling point :704.1±60.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :13.29±0.46(Predicted)
form :powder
color :white to beige
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :13.29±0.46(Predicted)
form :powder
color :white to beige
Safety Information
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Description
The wild-type p53-induced phosphatase Wip1, also known as protein phosphatase magnesium-dependent 1 delta (PPM1D) or PP2Cδ, modulates cell cycling and may contribute to some forms of cancer. GSK2830371 is a potent inhibitor of Wip1 (IC50 = 6 nM). It displays selectivity for Wip1 over 21 other phosphatases. GSK2830371 increases phosphorylation of Wip1 substrates and blocks cell cycling in hematopoietic cancer cells and in Wip1-amplified cancer cells with wild-type p53. This compound is orally bioavailable and causes inhibition of lymphoma xenograft growth in mice.Related product price
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