Goserelin acetate
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- ₹26423.83
- Product name: Goserelin acetate
- CAS: 145781-92-6
- MF: C61H88N18O16
- MW: 1329.49
- EINECS:652-995-1
- MDL Number:MFCD00867894
- Synonyms:PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2;[(T-BU)DSER6, (AZA)GLY10]-LH-RH;[(T-BU)DSER6, (AZA)GLY10]-LUTEINIZING HORMONE-RELEASING HORMONE;GOSERELIN HCL[PYR-HIS-TRP-SER-TYR-D-SER(T-BU)-LEU-ARG-PRO-AZAGLY-NH2];1-9-Luteinizing hormone-releasing factor (swine), 6-(o-(1,1-dimethylethyl)-D-serine)-, 2-(aminocarbonyl)hydrazide, acetate (salt);Fertilan;GLP-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZA-GLY-NH2;(D-SER(TBU)6,AZAGLY10)-LHRH
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberG4919
- Product descriptionGoserelin acetate ≥99% (HPLC), white, powder
- Packaging5MG
- Price₹26423.83
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G4919 | Goserelin acetate ≥99% (HPLC), white, powder | 5MG | ₹26423.83 | 2022-06-14 | Buy |
Properties
Melting point :>190°C (dec.)
storage temp. :-20°C
solubility :H2O: 20 mg/mL, clear, colorless
form :white powder
color :White to Off-White
Stability :Hygroscopic
InChIKey :IKDXDQDKCZPQSZ-JHYYTBFNSA-N
storage temp. :-20°C
solubility :H2O: 20 mg/mL, clear, colorless
form :white powder
color :White to Off-White
Stability :Hygroscopic
InChIKey :IKDXDQDKCZPQSZ-JHYYTBFNSA-N
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Goserelin acetate, like leuprolide acetate, is a synthetic superagonist nonapeptide analogue of GnRH that possesses greater potency than the natural hormone. Note that it contains D-Ser(But) and NH-NHCONH2 in place of Gly6 and Gly10-NH2, respectively. That is, the C terminal modification simply has an NH substituting for the CH2 of Gly, and like the C-terminal change in leuprolide acetate, this inhibits enzymatic degradation of the peptide by the postproline carboxyamide peptidase.Goserelin acetate is available in the form of a small, solid pellet that is administered as an SC implant for the palliative treatment of advanced, metastatic breast cancer in pre- and perimenopausal women or, similarly, as a palliative in advanced prostatic cancer. The rationale for this drug's use is, as described above, its ability as a superagonist to bring the levels of estradiol or testosterone to near castrate levels, thus slowing the progression of breast or prostate carcinoma, respectively. Additionally, goserelin acetate is approved for use in treating endometriosis for up to 6 months.
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