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ChemicalBook > Product Catalogue >API >Nervous system drugs >Cholinergic drugs >(-)-Huperzine A

(-)-Huperzine A

(-)-Huperzine A Structure
  • ₹2600 - ₹21444.33
  • Product name: (-)-Huperzine A
  • CAS: 102518-79-6
  • MF: C15H18N2O
  • MW: 242.32
  • EINECS:600-320-6
  • MDL Number:MFCD01714949
  • Synonyms:Huperzine-A1-5%;(5r-(5-alpha,9-beta,11e))-ydro-7-methyl ;5,9-methanocycloocta(b)pyridin-2(1h)-one,5-amino-11-ethylidene-5,6,9,10-tetrah ;HUPERIZINE;(-)-HUPERZINE A FROM HUPERZIA SERRATA;HuperziaSerrateP.E120786-18-7/;(5R,9R,E)-5-AMino-11-ethylidene-7-Methyl-5,6,9,10-tetrahydro-5,9-Methanocycloocta[b]pyridin-2(1H)-one;(-)-Huperzine A (HupA)
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 10MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberH1700
  • Product description(-)-Huperzine A
  • Packaging10MG
  • Price₹2600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberH1700
  • Product description(-)-Huperzine A
  • Packaging100MG
  • Price₹7800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number42643
  • Product description(−)-Huperzine A analytical standard
  • Packaging25MG
  • Price₹21444.33
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number H 1438
  • Product description(-)-Huperzine A+ 98%
  • Packaging25mg
  • Price₹18009
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) H1700 (-)-Huperzine A 10MG ₹2600 2022-05-26 Buy
TCI Chemicals (India) H1700 (-)-Huperzine A 100MG ₹7800 2022-05-26 Buy
Sigma-Aldrich(India) 42643 (−)-Huperzine A analytical standard 25MG ₹21444.33 2022-06-14 Buy
ottokemi H 1438 (-)-Huperzine A+ 98% 25mg ₹18009 2022-05-26 Buy

Properties

Melting point :211-216oC
alpha :D -147° (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4° (c = 0.498 in MeOH) (Liu)
Boiling point :505.0±50.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :insoluble in H2O; ≥12.12 mg/mL in DMSO; ≥23.13 mg/mL in EtOH
pka :12.25±0.60(Predicted)
form :Solid
color :White to Almost white
optical activity :[α]/D -153±5°, c = 0.5 in methanol
InChI :InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
InChIKey :ZRJBHWIHUMBLCN-YQEJDHNASA-N
SMILES :C12C[C@@]3([H])/C(=C\C)/[C@@](N)(C=1C=CC(=O)N2)CC(C)=C3
LogP :0.833 (est)
CAS DataBase Reference :102518-79-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Huperzine A is a natural sesquiterpene alkaloid first isolated from Huperzia, a club moss used in Chinese medicine for its neuroprotective activity. It inhibits acetylcholinesterase (AChE) in rat cortex in vitro (IC50 = 82 nM) and displays oral AChE inhibitory activity in animals. (?)-Huperzine A has potential applications in a variety of neuroprotective roles, including protection against organophosphate nerve agents and ameliorating symptoms of Alzheimer's disease.

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