Isoginkgetin
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- ₹22650
- Product name: Isoginkgetin
- CAS: 548-19-6
- MF: C32H22O10
- MW: 566.51
- EINECS:
- MDL Number:MFCD00597035
- Synonyms:2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one;2-(4-Methoxyphenyl)-8-[6-methoxy-3-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one;4',4'''-Dimethoxyamentoflavone;ISOGINKGETIN;8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;3''',8-Biflavone, 5,5'',7,7''-tetrahydroxy-4',4'''-dimethoxy-;4',4'''-Dimethylamentoflavone;ISOGINKGETIN(RG)(PLEASE CALL)
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Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number416154
- Product descriptionPre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem The Pre-mRNA Splicing Inhibitor, Isoginkgetin, also referenced under CAS 548-19-6, blocks the spliceosome-meidated splicing process.
- Packaging10MG
- Price₹22650
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 416154 | Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem The Pre-mRNA Splicing Inhibitor, Isoginkgetin, also referenced under CAS 548-19-6, blocks the spliceosome-meidated splicing process. | 10MG | ₹22650 | 2022-06-14 | Buy |
Properties
Melting point :355℃
Boiling point :843.6±65.0 °C(Predicted)
Density :1.506
storage temp. :2-8°C(protect from light)
solubility :DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
form :powder
pka :6.16±0.40(Predicted)
color :White-beige
InChIKey :HUOOMAOYXQFIDQ-UHFFFAOYSA-N
SMILES :C1(C2=CC=C(OC)C=C2)OC2=C(C3=CC(C4OC5=CC(O)=CC(O)=C5C(=O)C=4)=CC=C3OC)C(O)=CC(O)=C2C(=O)C=1
LogP :5.240 (est)
Boiling point :843.6±65.0 °C(Predicted)
Density :1.506
storage temp. :2-8°C(protect from light)
solubility :DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
form :powder
pka :6.16±0.40(Predicted)
color :White-beige
InChIKey :HUOOMAOYXQFIDQ-UHFFFAOYSA-N
SMILES :C1(C2=CC=C(OC)C=C2)OC2=C(C3=CC(C4OC5=CC(O)=CC(O)=C5C(=O)C=4)=CC=C3OC)C(O)=CC(O)=C2C(=O)C=1
LogP :5.240 (est)
Safety Information
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Description
Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing. Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; ) and LPS by approximately 87 and 90%, respectively. It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; ) and the calcium ionophore A23187 by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM. Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.Related product price
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