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ISRIB

ISRIB Structure
  • ₹0
  • Product name: ISRIB
  • CAS: 548470-11-7
  • MF: C22H24Cl2N2O4
  • MW: 451.34
  • EINECS:231-545-4
  • MDL Number:
  • Synonyms:ISRIB;N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE);ISRIB N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE);Integrated Stress Response inhibitor;trans-N,N′-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)-acetamide;2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide;N,N'-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide];
    2-(4-chlorophenoxy)-N-(4-{[(4-chlorophenoxy)acetyl]amino}cyclohexyl)acetami de
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :270-273°C
Boiling point :719.0±60.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble1mg/mL, clear (warmed)
pka :13.63±0.40(Predicted)
form :powder
color :white to beige
InChIKey :HJGMCDHQPXTGAV-UHFFFAOYSA-N
SMILES :C1(NC(=O)COC2=CC=C(Cl)C=C2)CCC(NC(=O)COC2=CC=C(Cl)C=C2)CC1

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

ISRIB (integrated stress response inhibitor) is an experimental drug that reverses the effects of eIF2α phosphorylation with an IC50 of 5 nM. It was discovered in the laboratory of Peter Walter at University of California, San Francisco (UCSF) through a semi-automated screening of a large library of small molecules by Carmela Sidrauski, who decided to pursue research on it. It has been shown to inhibit eIF2α phosphorylation-induced stress granule (SG) formation. Since eIF2α phosphorylation is known to be involved in memory formation, ISRIB was tested to see whether it would be active in vivo, and was found to readily cross the blood-brain barrier, with a half-life of eight hours.

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Suppliers and manufacturers

Wuhan Haorong Biotechnology Co.,ltd
ISRIB
₹0.00 /1kg
ISRIB CAS:548470-11-7
Hebei Kangcang new material Technology Co., LTD
ISRIB
₹9.00 /10g
ISRIB CAS:548470-11-7
career henan chemical co
N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE)
₹1.00 /1KG
N,N'-((1R,4R)-CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE) CAS:548470-11-7
A.J Chemicals
Xi'an MC Biotech, Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
TargetMol Chemicals Inc.