GSK2656157
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- ₹0
- Product name: GSK2656157
- CAS: 1337532-29-2
- MF: C23H21FN6O
- MW: 416.45
- EINECS:-0
- MDL Number:MFCD27997885
- Synonyms:GSK2656157;1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone;5-[4-Fluoro-1-[(6-methyl-2-pyridinyl)acetyl]-2,3-dihydro-1H-indol-5-yl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine GSK2656157;1-(5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyrid;GSK2656157(GSK-2656157);GSK2656157; GSK 2656157; GSK-2656157.;1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethan-1-one GSK2656157;PERK inhibitor GS2656157
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Properties
Melting point :194-196°C
Boiling point :744.6±60.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (10 mg/ml with warming)
form :solid
pka :5.32±0.30(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Boiling point :744.6±60.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (10 mg/ml with warming)
form :solid
pka :5.32±0.30(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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Description
GSK2656157 (1337532-29-2) is a potent (IC50 = 0.9 nM) and selective (over 300 kinases) inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERK).1,2? Inhibited growth of multiple human tumor xenografts in mice. GSK2656157 has also been found to potently inhibit RIPK1 (IC50 = 69 nM) and TNF-mediated RIPK1 kinase-dependent cell death in mouse embryonic fibroblasts.3 It prevented the loss of dendritic spines and rescued memory deficits after traumatic brain injury.4? GSK2656157 also enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes mellitus.5More related product prices
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