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ChemicalBook > Product Catalogue >Biochemical Engineering >Chinese Herbs >Isoalantolactone

Isoalantolactone

Isoalantolactone Structure
  • ₹0
  • Product name: Isoalantolactone
  • CAS: 470-17-7
  • MF: C15H20O2
  • MW: 232.32
  • EINECS:
  • MDL Number:MFCD08689940
  • Synonyms:11(13)-dien-12-oicacid,8-beta-hydroxy-eudesma-4(14gamma-lactone ;ISOALANTOACTONE;ISOALANTOLACTONE;ISOHELENIN;(3ar,4as,8ar,9ar)-8a-methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one;methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-;Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a-;(3aR)-3aα,4,4aα,5,6,7,8,8a,9,9aα-Decahydro-3,5-bismethylene-8aβ-methylnaphtho[2,3-b]furan-2(3H)-one
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :115℃
Boiling point :364.9±42.0 °C(Predicted)
Density :1.07±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml) or ethanol (30 mg/ml)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
LogP :3.420
CAS DataBase Reference :470-17-7(CAS DataBase Reference)
NIST Chemistry Reference :Naphtho(2,3-b)furan-2(3h)-one, decahydro-8a-methyl-3,5-bis(methylene)-, (3ar-(3a«alpha»,4a«alpha»,8a«beta»,9a«alpha»))-(470-17-7)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P321 Specific treatment (see … on this label).
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Isohelenin (470-17-7) is a sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 μM)1 acting via inhibition of IKK?6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression2, iNOS expression3 and RANTES biosynthesis4. Displays protective effects in endotoxic shock in rodent models.5 Induces apoptosis in glioma cells.6

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