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ChemicalBook > Product Catalogue >Biochemical Engineering >Chinese Herbs >Isoimperatorin

Isoimperatorin

Isoimperatorin Structure
  • ₹54796.15
  • Product name: Isoimperatorin
  • CAS: 482-45-1
  • MF: C16H14O4
  • MW: 270.28
  • EINECS:801-715-8
  • MDL Number:MFCD00272155
  • Synonyms:ISOIMPERATORIN;4-PRENYLOXYPSORALEN;4-(3-Methyl-but-2-enyloxy-furo[3,2-g]chromen-7-one;ISOIMPERATORIN(P);Isomperatorin;4-(3-Methylbut-2-enoxy)furo[3,2-g]chromen-7-one;4-(3-Methyl-but-2-enyloxy-furo[3,2-γ],chromen-7-one;7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-
Price1 Properties Safety Information Description
1 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product number68771
  • Product descriptionIsoimperatorin analytical standard
  • Packaging10MG
  • Price₹54796.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 68771 Isoimperatorin analytical standard 10MG ₹54796.15 2022-06-14 Buy

Properties

Melting point :107-111°C
Boiling point :448.3±45.0 °C(Predicted)
Density :1.242±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Chloroform (Sparingly), Ethyl Acetate (Slightly
form :Solid
color :White to Pale Yellow
BRN :1291723
LogP :3.495 (est)
CAS DataBase Reference :482-45-1(CAS DataBase Reference)
NIST Chemistry Reference :7H-furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-butenyl)oxy]-(482-45-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Isoimperatorin is an anti-inflammatory agent, that also has an effect on proliferation, isolated from the dried roots of Angelicae dahuricae. In bone marrow derived mast cells the compound has been observed to inhibit, at an IC50 24 μM and 10.7 μM, COX-1 and COX-2-dependent phases of prostaglandin D2 generation. In the same cells the compound also inhibited the production of leukotriene D4, demonstrating Isoimperatorin’s 5-lipoxygenase inhibitory activity. On prostate cancer cell line DU145 Isoimperatorin impaired proliferation with arrest at G1 and induced cell death. The compound also displayed chemopreventive effects against aflatoxin B-1 on H4IIE cells by increasing GSTα activity. In addition, Isoimperatorin at 2 μM completely abolished 3-methylchoranthrene-inducible CYP1A activity.

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