JNJ 31020028
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- Product name: JNJ 31020028
- CAS: 1094873-14-9
- MF: C34H36FN5O2
- MW: 565.68
- EINECS:
- MDL Number:MFCD18782744
- Synonyms:JNJ 31020028;N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide;N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide;4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE;JNJ31020028, >98%;JNJ-31020028?, >98%;CS-1745;JNJ-31020028;JNJ 31020028
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Properties
Boiling point :677.5±55.0 °C(Predicted)
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 21.5 mg/mL (38.01 mM; Need ultrasonic and warming)
form :Powder
pka :12.14±0.70(Predicted)
color :Light yellow to yellow
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 21.5 mg/mL (38.01 mM; Need ultrasonic and warming)
form :Powder
pka :12.14±0.70(Predicted)
color :Light yellow to yellow
Safety Information
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Description
JNJ-31020028 is a brain-permeable selective antagonist of the neuropeptide Y (NPY) receptor Y2 (IC50s = 8.51, 6.03, and 6.17 nM for human, rat, and mouse receptors, respectively) with over 100-fold selectivity for Y2 over Y1, Y4, and Y5 receptors. JNJ-31020028 inhibits calcium release induced by peptide YY in a functional assay in KAN-TS cells (pKB = 8.04) and blocks NPY(13-36)-induced decreases in twitch contraction amplitude in isolated rat vas deferens (IC50 = 7.94 nM). Administration of JNJ-31020028 to rats during abstinence (20 mg/kg per day, i.p.) reverses nicotine-induced social anxiety-like behavior and increases hippocampal Y2 receptor mRNA levels. It reverses withdrawal-induced anxiety-like behavior in rats in the elevated plus maze following a single bolus dose of alcohol when administered at a dose of 15 mg/kg. In an olfactory bulbectomized rat model of depression, chronic JNJ-31020028 treatment (10 nmol per day, i.c.v.) decreases immobility time in the forced swim test but has no effect in control animals.More related product prices
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