KL001
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- ₹10110.55 - ₹40886.03
- Product name: KL001
- CAS: 309928-48-1
- MF: C21H22N2O4S
- MW: 398.48
- EINECS:
- MDL Number:MFCD02086647
- Synonyms:N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide;N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide;Methanesulfonamide, N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-;KL001(KL-001;Inhibitor,inhibit,stabilizer,KL001,circadian,cryptochrome,ubiquitin,period,gluconeogenesis,CRY
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1032
- Product descriptionKL001 ≥98% (HPLC)
- Packaging5MG
- Price₹10110.55
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1032
- Product descriptionKL001 ≥98% (HPLC)
- Packaging25MG
- Price₹40886.03
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1032 | KL001 ≥98% (HPLC) | 5MG | ₹10110.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1032 | KL001 ≥98% (HPLC) | 25MG | ₹40886.03 | 2022-06-14 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
solubility :DMSO: soluble20mg/mL, clear
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The cryptochrome proteins CRY1 and CRY2, which play central roles in maintaining the circadian clock, are expressed and then degraded in a rhythmic pattern. KL001 is a cell-permeable carbazolic compound which directly interacts with and stabilizes CRY1 and CRY2, preventing ubiquitin-dependent degradation while lengthening the circadian period (IC50 = 0.82-14 μM). As the expression of some gluconeogenic genes is both circadian and cryptochrome-dependent, KL001 effectively inhibits glucagon-induced gluconeogenesis in primary hepatocytes. This product can be used to study the regulation of cryptochrome-dependent physiology and aid in the development of clock-based therapeutics of diabetes.Related product price
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Suppliers and manufacturers
CLEARSYNTH LABS LTD.
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Sigma-Aldrich
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Shanghai Rechem science Co., Ltd.
Hangzhou FuRun Pharmaceutical Technology Co., Ltd