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KT5720

KT5720 Structure
  • ₹14259.99 - ₹26207.33
  • Product name: KT5720
  • CAS: 108068-98-0
  • MF: C32H31N3O5
  • MW: 537.61
  • EINECS:810-587-2
  • MDL Number:MFCD09878277
  • Synonyms:(9R,10S,12S)-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID, HEXYL ESTER;KT5720;PROTEIN KINASE INHIBITOR KT 5720;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10S,12S)-;(9s,10s,12r)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-I][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10R,12S)-rel-;Aids004395;Aids-004395
Price4 Properties Safety Information Description
4 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 0.1MG
  • 100μG
  • 50μG
  • ManufacturerSigma-Aldrich(India)
  • Product number420323
  • Product descriptionInSolution KT5720 - CAS 108068-98-0 - Calbiochem
  • Packaging50μG
  • Price₹14259.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number420320
  • Product descriptionKT5720 - CAS 108068-98-0 - Calbiochem A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modificat
  • Packaging50μG
  • Price₹14260
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number420320
  • Product descriptionKT5720 - CAS 108068-98-0 - Calbiochem A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modificat
  • Packaging100μG
  • Price₹23839.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberK3761
  • Product descriptionKT 5720 ≥98% (HPLC), powder
  • Packaging0.1MG
  • Price₹26207.33
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 420323 InSolution KT5720 - CAS 108068-98-0 - Calbiochem 50μG ₹14259.99 2022-06-14 Buy
Sigma-Aldrich(India) 420320 KT5720 - CAS 108068-98-0 - Calbiochem A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modificat 50μG ₹14260 2022-06-14 Buy
Sigma-Aldrich(India) 420320 KT5720 - CAS 108068-98-0 - Calbiochem A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modificat 100μG ₹23839.99 2022-06-14 Buy
Sigma-Aldrich(India) K3761 KT 5720 ≥98% (HPLC), powder 0.1MG ₹26207.33 2022-06-14 Buy

Properties

Boiling point :715.0±60.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :methanol: 5 mg/mL
form :powder
pka :11.96±0.40(Predicted)
color :white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp. It blocks PKA signaling through competitive inhibition of ATP with a Ki value of 60 nM. Reported IC50 values vary widely depending upon ATP concentration tested and can range from 56 nM (low ATP) to 3 μM (physiologic ATP). Non-specific effects of KT 5720 include inhibition of phosphorylase kinase, PDK1, MEK, MSK1, PKBα, and GSK3β at concentrations as effective as or more potent than that for inhibition of PKA.

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