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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and proteins >L-KYNURENINE

L-KYNURENINE

L-KYNURENINE Structure
  • ₹3236.68 - ₹34250.3
  • Product name: L-KYNURENINE
  • CAS: 2922-83-0
  • MF: C10H12N2O3
  • MW: 208.21
  • EINECS:
  • MDL Number:MFCD00069912
  • Synonyms:L-2-AMINO-3-(2-AMINOBENZOYL)PROPIONIC ACID;L-2-AMINO-4-[2-AMINOPHENYL]-4-OXOBUTANOIC ACID;L-KYNURENINE;L-kynurenine free base;β-Anthraniloyl-L-alanine;β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid;L-Kynurenine Hydrate;(S)-2-Amino-4-oxo-4-(2-aminophenyl)butanoic acid
6 prices
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Brand

  • ALFA India
  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 25MG
  • 50mg
  • 100MG
  • 500MG
  • 1G
  • ManufacturerALFA India
  • Product numberALF-J60199-MF
  • Product descriptionL-Kynurenine
  • Packaging50mg
  • Price₹6381
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberK0016
  • Product descriptionL-Kynurenine
  • Packaging100MG
  • Price₹5200
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberK8625
  • Product descriptionL-Kynurenine ≥98% (HPLC)
  • Packaging25MG
  • Price₹3236.68
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberK8625
  • Product descriptionL-Kynurenine ≥98% (HPLC)
  • Packaging100MG
  • Price₹8075.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberK8625
  • Product descriptionL-Kynurenine ≥98% (HPLC)
  • Packaging500MG
  • Price₹16443.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberK8625
  • Product descriptionL-Kynurenine ≥98% (HPLC)
  • Packaging1G
  • Price₹34250.3
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ALFA India ALF-J60199-MF L-Kynurenine 50mg ₹6381 2022-05-26 Buy
TCI Chemicals (India) K0016 L-Kynurenine 100MG ₹5200 2022-05-26 Buy
Sigma-Aldrich(India) K8625 L-Kynurenine ≥98% (HPLC) 25MG ₹3236.68 2022-06-14 Buy
Sigma-Aldrich(India) K8625 L-Kynurenine ≥98% (HPLC) 100MG ₹8075.45 2022-06-14 Buy
Sigma-Aldrich(India) K8625 L-Kynurenine ≥98% (HPLC) 500MG ₹16443.18 2022-06-14 Buy
Sigma-Aldrich(India) K8625 L-Kynurenine ≥98% (HPLC) 1G ₹34250.3 2022-06-14 Buy

Properties

Melting point :219 °C
Boiling point :466.6±45.0 °C(Predicted)
Density :1.343±0.06 g/cm3(Predicted)
refractive index :-33 ° (C=0.4, H2O)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml).
form :crystalline
pka :2.21±0.23(Predicted)
color :light yellow
Merck :14,5328
Stability :Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey :YGPSJZOEDVAXAB-QMMMGPOBSA-N
CAS DataBase Reference :2922-83-0(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Kynurenine is a product of constitutive tryptophan catabolism via tryptophan-2,3-dioxygenase in the liver and human gliomas that is associated with the suppression of antitumor immune responses. At 100 μM, kynurenine inhibits allogeneic T-cell proliferation and increases malignant U87 glioma cell invasion into a collagen matrix. Kynurenine activates the aryl hydrocarbon receptor (AhR) target gene CYP1A1 with an EC50 value of 12.3 μM and binds to AhR with an apparent Kd value of ~4 μM. Kynurenine is ultimately metabolized to quinolinic acid, a potent neurotoxin that acts as an NMDA agonist and has been described to be involved in neurodegenerative processes in the brain.

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