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ChemicalBook > Product Catalogue >API >Urinary System Drugs >Diuretics Drugs >Metolazone

Metolazone

Metolazone Structure
  • ₹14624.58 - ₹63001.5
  • Product name: Metolazone
  • CAS: 17560-51-9
  • MF: C16H16ClN3O3S
  • MW: 365.83
  • EINECS:241-539-3
  • MDL Number:MFCD00069304
  • Synonyms:s720-22 ;7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, SR-720-22, Diulo, Metenix, Mykrox, Oldren,;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- (9CI);6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);Normelan;Xuret;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro- 2-methyl-3-(2-methylphenyl)-4-oxo-;METAZOLINE
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberM1195
  • Product descriptionMetolazone ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹14624.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM1195
  • Product descriptionMetolazone ≥98% (HPLC), solid
  • Packaging25MG
  • Price₹63001.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) M1195 Metolazone ≥98% (HPLC), solid 5MG ₹14624.58 2022-06-14 Buy
Sigma-Aldrich(India) M1195 Metolazone ≥98% (HPLC), solid 25MG ₹63001.5 2022-06-14 Buy

Properties

Melting point :252-254°C
Boiling point :613.6±65.0 °C(Predicted)
Density :1.2895 (rough estimate)
refractive index :1.6100 (estimate)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :pKa 9.7 (Uncertain)
form :solid
color :white
Water Solubility :60.3mg/L(25 ºC)
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
InChIKey :AQCHWTWZEMGIFD-UHFFFAOYSA-N
CAS DataBase Reference :17560-51-9(CAS DataBase Reference)
NIST Chemistry Reference :Metolazone(17560-51-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Metolazone is a thiazide-like diuretic that targets the Na+-Cl- cotransporter responsible for salt reabsorption in the distal convoluted tubule of the kidney (IC50 = 0.3 μM in rat). It is also a potent inhibitor of human carbonic anhydrase isoforms VII, XII, and XIII (Kis = 2.1, 5.4, and 15 nM, respectively), which have crucial functions in renal physiology. Metolazone has been predominantly used in the treatment of congestive heart failure and high blood pressure.

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