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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Anti-Congestive Heart Failure drugs >Milrinone

Milrinone

Milrinone Structure
  • ₹4900 - ₹96180.13
  • Product name: Milrinone
  • CAS: 78415-72-2
  • MF: C12H9N3O
  • MW: 211.22
  • EINECS:278-903-6
  • MDL Number:MFCD00133539
  • Synonyms:Corotrope;Milrila;3-CYANO-6-METHYL-5-(4-PYRIDYL)-2-PYRIDONE;6-METHYL-5-(4-PYRIDYL)-2-PYRIDONE-3-CARBONITRILE;1,6-DIHYDRO-2-METHYL-6-OXO-(3,4'-BIPYRIDINE)-5-CARBONITRILE;6-Methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile;YM-018;2-Oxo-5-(4-pyridyl)-6-methyl-1,2-dihydropyridine-3-carbonitrile
Price8 Properties Safety Information Description
8 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 10MG
  • 50MG
  • 100MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberM1663
  • Product descriptionMilrinone
  • Packaging100MG
  • Price₹4900
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberM1663
  • Product descriptionMilrinone
  • Packaging1G
  • Price₹17400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM4659
  • Product descriptionMilrinone ≥97% (TLC), powder
  • Packaging10MG
  • Price₹24410.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number475840
  • Product descriptionMilrinone - CAS 78415-72-2 - Calbiochem A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC?? = 300 nM).
  • Packaging10MG
  • Price₹27450.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2515
  • Product descriptionMilrinone Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹28361.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM4659
  • Product descriptionMilrinone ≥97% (TLC), powder
  • Packaging50MG
  • Price₹96180.13
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number M 0699
  • Product descriptionMilrinone, ≥98%
  • Packaging10mg
  • Price₹18909
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number M 0699
  • Product descriptionMilrinone, ≥98%
  • Packaging50mg
  • Price₹74079
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) M1663 Milrinone 100MG ₹4900 2022-05-26 Buy
TCI Chemicals (India) M1663 Milrinone 1G ₹17400 2022-05-26 Buy
Sigma-Aldrich(India) M4659 Milrinone ≥97% (TLC), powder 10MG ₹24410.38 2022-06-14 Buy
Sigma-Aldrich(India) 475840 Milrinone - CAS 78415-72-2 - Calbiochem A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC?? = 300 nM). 10MG ₹27450.01 2022-06-14 Buy
Sigma-Aldrich(India) PHR2515 Milrinone Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹28361.5 2022-06-14 Buy
Sigma-Aldrich(India) M4659 Milrinone ≥97% (TLC), powder 50MG ₹96180.13 2022-06-14 Buy
ottokemi M 0699 Milrinone, ≥98% 10mg ₹18909 2022-05-26 Buy
ottokemi M 0699 Milrinone, ≥98% 50mg ₹74079 2022-05-26 Buy

Properties

Melting point :>3000C
Boiling point :350.9°C (rough estimate)
Density :1.1922 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :2-8°C
solubility :DMSO: >10 mg/mL
form :powder
pka :7.21±0.10(Predicted)
color :off-white
Water Solubility :Soluble in DMSO. Insoluble in water.
Merck :14,6197
Stability :Stable. Incompatible with strong oxidizing agents.
InChIKey :FYEJSUDMDUIMKJ-UHFFFAOYSA-N
CAS DataBase Reference :78415-72-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:

Description

Phosphodiesterase 3 (PDE3) family members have high-affinities for both cAMP and cGMP and show cGMP-dependent inhibition of cAMP hydrolysis. Milrinone is a potent inhibitor of type 3 phosphodiesterases (PDEs), inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1.0 μM, respectively. It less effectively inhibits other PDE isoforms, with IC50 values of 263, >300, 17.5, 49.1, and 58.3 μM for PDE1, PDE2, PDE4, PDE5, and PDE7, respectively. Milrinone has positive inotropic (stimulates cardiac muscle contractions) and vasodilatory effects when administered in vivo.

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Suppliers and manufacturers

GLR Innovations Sai Life Sciences Ltd Omshri Labs Pvt Ltd Sai Life Sciences Ltd. (formerly Sai Advantium Pharma Limited) Indogulf Group Shivam Pharma Chemicals EMCURE PHARMACEUTICALS LTD A.J Chemicals CLEARSYNTH LABS LTD. Otto Chemie Pvt. Ltd.