Nitrocefin
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- Product name: Nitrocefin
- CAS: 41906-86-9
- MF: C21H16N4O8S2
- MW: 516.5
- EINECS:
- MDL Number:MFCD12165893
- Synonyms:3-(2,4-DINITROSTYRYL)-(6R, 7R)-7-(2-THIENYLACETAMIDO)-CEPH-3-EM-4 CARBOXYLIC ACID, E-ISOMER;(6R)-3-[(E)-2-(2,4-Dinitrophenyl)ethenyl]-8-oxo-7α-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Nitrocefin (>90%);(6R,7R)-3-[(E)-2-(2,4-dinitrophenyl)ethenyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;NITROCEFIN;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1E)-2-(2,4-dinitrophenyl)ethenyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7R)-;Nitrocefin (>3-[(E)-2-(2,4-Dinitrophenyl)vinyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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Properties
Melting point :103-113° (dec); mp 167-169° (dec) (Lee)
alpha :D20 -224° (c = 1.0 in dioxane)
Boiling point :872.0±65.0 °C(Predicted)
Density :1.67±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml
form :A crystalline solid
pka :2.50±0.50(Predicted)
color :Yellow to orange
Stability :Hygroscopic, Unstable in Solution
alpha :D20 -224° (c = 1.0 in dioxane)
Boiling point :872.0±65.0 °C(Predicted)
Density :1.67±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml
form :A crystalline solid
pka :2.50±0.50(Predicted)
color :Yellow to orange
Stability :Hygroscopic, Unstable in Solution
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The generation of β-lactamases by bacteria affords resistance to several classes of β-lactam antibiotics, including penicillins and cephalosporins. Nitrocefin is a chromogenic cephalosporin substrate commonly used to detect β-lactamases in bacteria. The presence of β-lactamase activity is indicated by the appearance of a red color that is proportional in intensity to the original concentration of nitrocefin.Related product price
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