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ChemicalBook > Product Catalogue >API >Specialty drugs >Antidote >Naloxone

Naloxone

Naloxone Structure
  • ₹0
  • Product name: Naloxone
  • CAS: 465-65-6
  • MF: C19H21NO4
  • MW: 327.37
  • EINECS:207-365-7
  • MDL Number:MFCD00242634
  • Synonyms:12-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4ah-8,9c-iminoethanophenanthro(4,5 ;12-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4ah-8,9c-iminoethanophenanthro[4,5 ;17-allyl-4,5alpha-epoxy-3,14-dihydroxy-morphinan-6-on ;17-allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one ;17-allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one ;1-n-allyl-14-hydroxynordihydromorphinone ;1-n-allyl-7,8-dihydro-14-hydroxynormorphinone ;4,5-alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-on
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :184° (Lewenstein), 177-178° (Sankyo Co.)
alpha :D20 -194.5° (c = 0.93 in CHCl3)
Boiling point :465.27°C (rough estimate)
Density :1.2223 (rough estimate)
refractive index :1.5000 (estimate)
Flash point :9℃
storage temp. :2-8°C
solubility :Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly),
form :Solid
pka :pKa 7.94/7.82(H2O,t =20/37,I<0.01) (Uncertain)
color :White to Off-White
InChIKey :UZHSEJADLWPNLE-GRGSLBFTSA-N
EPA Substance Registry System :Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5.alpha.)- (465-65-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501 Dispose of contents/container to..…

Description

It is worth mentioning that N-allylic substitution in a number of morphine derivatives, as a rule, leads to antagonistic properties. Naloxone is a few times stronger than nalorphine as an antagonist. It blocks opiate receptors. It eliminates central and peripheral action of opioids, including respiratory depression. Naloxone is used upon overdose of narcotic analgesics.

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ETHYLENE OXIDE Propylene oxide Epichlorohydrin Naloxone hydrochloride 51481-60-8

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Suppliers and manufacturers

CLEARSYNTH LABS LTD. Pharmaffiliates Analytics and Synthetics P. Ltd
Henan Tianfu Chemical Co.,Ltd.
CONIER CHEM AND PHARMA LIMITED
Shaanxi Dideu Medichem Co. Ltd
Zhejiang J&C Biological Technology Co.,Limited
LEAP CHEM CO., LTD.
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific Shanghai Aladdin Biochemical Technology Co.,Ltd.