Nexturastat A
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- ₹0
- Product name: Nexturastat A
- CAS: 1403783-31-2
- MF: C19H23N3O3
- MW: 341.4
- EINECS:
- MDL Number:MFCD28099804
- Synonyms:Nexturastat A, >=98%;4-[[Butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxybenzamide;Nexturastat A;4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE;Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-;Nexturastat A 4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE;Nexturastat A Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-;4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
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Properties
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.3 mg/mL in DMSO; ≥9.3 mg/mL in EtOH
form :solid
pka :8.95±0.10(Predicted)
color :White to off-white
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.3 mg/mL in DMSO; ≥9.3 mg/mL in EtOH
form :solid
pka :8.95±0.10(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Nexturastat A is a potent inhibitor of HDAC6 (IC50 = 5.02 nM) that displays high selectivity over all other HDACs. It dose-dependently induces hyperacetylation of α-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation. Nexturastat A is cell-permeable and inhibits the proliferation of B16 cells (GI50 = 14.3 μM).Related product price
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