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ChemicalBook > Product Catalogue >API >Antiparasitic drugs >Antimalarial drug >Niclosamide

Niclosamide

Niclosamide Structure
  • ₹4630.01 - ₹41049
  • Product name: Niclosamide
  • CAS: 50-65-7
  • MF: C13H8Cl2N2O4
  • MW: 327.12
  • EINECS:200-056-8
  • MDL Number:MFCD00057597
  • Synonyms:Nc osamide;NICLOSAMID PESTANAL 250 MG;NICLOSAMID PESTANAL;2-CHLORO-4-NITROHENYLAMIDE-6-CHLOROSALICYLIC ACID;Niclosamide 1420-04-8,;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza;Niclosamide (base and/or unspecified salts);5-CHLORO-N-(2-CHLORO-5-NITROPHENYL)-2-HYDROXYBENZAMIDE
5 prices
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Brand

  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 1G
  • 50gm
  • 50G
  • 250gm
  • 250G
  • ManufacturerSigma-Aldrich(India)
  • Product number481909
  • Product descriptionNiclosamide - CAS 50-65-7 - Calbiochem A salicylanilide anthelmintic drug that acts as a potent and selective Stat3- and Wnt-signaling pathway inhibitor.
  • Packaging1G
  • Price₹4630.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN3510
  • Product descriptionNiclosamide
  • Packaging50G
  • Price₹11961.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN3510
  • Product descriptionNiclosamide
  • Packaging250G
  • Price₹30851.25
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number N 0636
  • Product descriptionNiclosamide 98%
  • Packaging50gm
  • Price₹10809
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number N 0636
  • Product descriptionNiclosamide 98%
  • Packaging250gm
  • Price₹41049
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 481909 Niclosamide - CAS 50-65-7 - Calbiochem A salicylanilide anthelmintic drug that acts as a potent and selective Stat3- and Wnt-signaling pathway inhibitor. 1G ₹4630.01 2022-06-14 Buy
Sigma-Aldrich(India) N3510 Niclosamide 50G ₹11961.63 2022-06-14 Buy
Sigma-Aldrich(India) N3510 Niclosamide 250G ₹30851.25 2022-06-14 Buy
ottokemi N 0636 Niclosamide 98% 50gm ₹10809 2022-05-26 Buy
ottokemi N 0636 Niclosamide 98% 250gm ₹41049 2022-05-26 Buy

Properties

Melting point :225-230°
Boiling point :424.5±45.0 °C(Predicted)
Density :1.6646 (rough estimate)
refractive index :1.6200 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :acetone: methanol: soluble50mg/mL (methanol:acetone (1:1))
form :Pale yellow solid
pka :7.45±0.43(Predicted)
color :Yellow
Water Solubility :13.32mg/L(25 ºC)
BRN :2820605
BCS Class :4
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :RJMUSRYZPJIFPJ-UHFFFAOYSA-N
CAS DataBase Reference :50-65-7(CAS DataBase Reference)
EPA Substance Registry System :Niclosamide (50-65-7)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Niclosamide is a salicylanilide compound with antihelminthic actions. It specifically inhibits the signal transducer and activator of transcription 3 (STAT3) with an IC50 value of 0.25 μM. It does not decrease the level or activity of the related STAT1, STAT5, JAK, or Src kinases. Through its effects on STAT3, niclosamide inhibits the proliferation and colony formation of Du145 prostate cancer cells, which have constitutively active STAT3, with IC50 values of 0.7 and 0.1 μM, respectively.

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