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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Epigenetics >Epigenetic Reader Domain inhibitors >OF-1

OF-1

OF-1 Structure
  • ₹14440.55
  • Product name: OF-1
  • CAS: 919973-83-4
  • MF: C17H18BrN3O4S
  • MW: 440.31
  • EINECS:604-604-1
  • MDL Number:MFCD26964046
  • Synonyms:OF-1;4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide;4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide;OF-1 USP/EP/BP;Benzenesulfonamide, 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-;4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-methylbenzenesulfonamide;OF-1;OF1;CS-1634
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1184
  • Product descriptionOF-1 ≥98% (HPLC)
  • Packaging5MG
  • Price₹14440.55
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1184 OF-1 ≥98% (HPLC) 5MG ₹14440.55 2022-06-14 Buy

Properties

Boiling point :573.8±60.0 °C(Predicted)
Density :1.557±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :9.44±0.20(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

OF-1 is a chemical probe for the bromodomains of the Bromodomain and PHD Finger-containing (BRPF) family of proteins. It binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.5, and 2.4 μM, respectively, as determined by isothermal titration calorimetry. OF-1 increases thermal stability of full length BRPF1B at 1 μM, in the cellular thermal shift assay. It also demonstrates accelerated fluorescence recovery after photobleaching (FRAP) at 5 μM in the BRPF2 FRAP assay. OF-1 shows modest general cytotoxicity. See the Structural Genomics Consortium (SGC) website for further information.

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