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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >protein tyrosine kinase >Foretinib (GSK1363089)

Foretinib (GSK1363089)

Foretinib (GSK1363089) Structure
  • ₹0
  • Product name: Foretinib (GSK1363089)
  • CAS: 849217-64-7
  • MF: C34H34F2N4O6
  • MW: 632.65
  • EINECS:
  • MDL Number:MFCD22379992
  • Synonyms:GSK 1363089;N-[3-Fluoro-4-[[6-(methyloxy)-7-[[3-(morpholin-4-yl)propyl]oxy]quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide;XL-880,Foretinib;XL880(GSK1363089);FORETINIB GLAXOSMITHKLINE PAPILLARY RENAL CELL CARCINOMA PHASE IIRSCH. TRIANGLE PARK, NC (SEE ALSO HEAD/NECK) (888) 825-5249;foretinib N1-{3-fluoro-4-[(6-(Methyloxy)-7-{[3-(4-Morpholinyl)propyl]oxy}-4-quinolinyl)oxy]phenyl}-N1'-(4-fluorophenyl)-1,1-cyclopropanedicarboxaMide;Foretinib (GSK1363089, XL880)
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>98°C (dec.)
Boiling point :828.5±65.0 °C(Predicted)
Density :1.372
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Ethanol (Slightly)
pka :13.14±0.70(Predicted)
form :Yellow powder.
color :Pale Yellow to Yellow
CAS DataBase Reference :849217-64-7

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314 Get medical advice/attention if you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.

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Suppliers and manufacturers

career henan chemical co
Foretinib (GSK1363089)
₹2.00 /1kg
Foretinib (GSK1363089) CAS:849217-64-7
CLEARSYNTH LABS LTD. A.J Chemicals
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited