Ozagrel
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- ₹0
- Product name: Ozagrel
- CAS: 82571-53-7
- MF: C13H12N2O2
- MW: 228.25
- EINECS:919-112-4
- MDL Number:MFCD00868231
- Synonyms:(E)-4-(1-Imidazoylmethyl)cinnamic acid;2-Propenoic acid, 3-[4-(1H-imidazol-1-ylmethyl)phenyl]-, (2E)-;(E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]propenoic acid;(E)-3-[p-(1H-Imidazol-1-ylmethyl)phenyl]acrylic acid;3-[4-(1H-IMIDAZOL-1-YLMETHYL)PHENYL]-2E-PROPENOIC ACID;Ozagrel API;Ozagrel(OKY-046);(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid
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Properties
Melting point :223-224°
Boiling point :468.0±25.0 °C(Predicted)
Density :1.17±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO : 50 mg/mL (219.06 mM; Need ultrasonic)
form :Powder
pka :4.43±0.10(Predicted)
color :White to off-white
CAS DataBase Reference :82571-53-7(CAS DataBase Reference)
Boiling point :468.0±25.0 °C(Predicted)
Density :1.17±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO : 50 mg/mL (219.06 mM; Need ultrasonic)
form :Powder
pka :4.43±0.10(Predicted)
color :White to off-white
CAS DataBase Reference :82571-53-7(CAS DataBase Reference)
Safety Information
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Signal word: | Warning | ||||||||||||||
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Description
Inhibition of thromboxane synthase (TXAS), especially in human platelets, has been a clinical objective for many years. 1-Alkyl (N-alkyl)-imidazole derivatives have been recognized as TXAS inhibitors since the early 1980s. Ozagrel is a 1-alkyl imidazole derivative that acts as a selective inhibitor of TXAS with an IC50 of 11 nM. The beneficial effects of TXAS inhibition by ozagrel include improved motor coordination after experimental stroke, and antihypertensive effects in spontaneously hypertensive rats.Related product price
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