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ChemicalBook > Product Catalogue >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >PARECOXIB SODIUM

PARECOXIB SODIUM

PARECOXIB SODIUM Structure
  • ₹0
  • Product name: PARECOXIB SODIUM
  • CAS: 198470-85-8
  • MF: C19H19N2NaO4S
  • MW: 394.42
  • EINECS:813-689-5
  • MDL Number:
  • Synonyms:N-[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)PHENYLSULFONYL]PROPIONAMIDE, SODIUM SALT;Parecoxib sodiuM salt;N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanaMide SodiuM Salt;Rayzon;SC 69124A;PropanaMide,N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodiuM salt (1:1);Parecoxib sodiuM cloth;Parecoxib sodium N-[4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide sodium salt
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :273-275°C
storage temp. :Inert atmosphere,2-8°C
solubility :DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
form :Powder
color :White to off-white
InChI :InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22);;
InChIKey :OGSQVUBPCQXSGW-UHFFFAOYSA-N
SMILES :CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).

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5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL 5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole 2-Phenylacetophenone 138786-67-1 VALDECOXIB DeoxyBenzoinOxime 37928-17-9

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Suppliers and manufacturers

Hetero Drugs Limited Nuray Chemicals Pvt Ltd Aruvi Labs Lifecare Laboratories Pvt. Ltd A.J Chemicals CLEARSYNTH LABS LTD. Aegis Pharma Chem SynZeal Research Pvt Ltd S. Zhaveri Pharmakem Pvt. Ltd Vedan Healthcare