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PNU 100480

PNU 100480 Structure
  • ₹11420.38 - ₹46515.03
  • Product name: PNU 100480
  • CAS: 168828-58-8
  • MF: C16H20FN3O3S
  • MW: 353.41
  • EINECS:
  • MDL Number:MFCD00937821
  • Synonyms:PNU 100480;(S)-N-[[3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide;Sutezolid;(S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide;(S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide(WXC06631);PF-02341272;Sutezolid (PNU-100480, PF-02341272);PNU-100480; U-100480; PF-02341272
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0035
  • Product descriptionSutezolid ≥98% (HPLC)
  • Packaging5MG
  • Price₹11420.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0035
  • Product descriptionSutezolid ≥98% (HPLC)
  • Packaging25MG
  • Price₹46515.03
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0035 Sutezolid ≥98% (HPLC) 5MG ₹11420.38 2022-06-14 Buy
Sigma-Aldrich(India) PZ0035 Sutezolid ≥98% (HPLC) 25MG ₹46515.03 2022-06-14 Buy

Properties

Melting point :186-187°C
Boiling point :609.0±55.0 °C(Predicted)
Density :1.321±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :15.53±0.46(Predicted)
color :white to beige
optical activity :[α]/D -8 to -12°, c = 1 in chloroform-d

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.

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