POLYPHYLLIN D
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- Product name: POLYPHYLLIN D
- CAS: 50773-41-6
- MF: C44H70O16
- MW: 855.02
- EINECS:
- MDL Number:MFCD12407435
- Synonyms:POLYPHYLLIN D;Polyphyllin;Polyphyllin I;Polyphyllin C;Paris saponin Pa;Polyphillin D;Polyphyllin A;Paridis saponin I
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Properties
Melting point :>245°C (dec.)
Density :1.40
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly)
pka :12?+-.0.70(Predicted)
form :Solid
color :White
Density :1.40
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly)
pka :12?+-.0.70(Predicted)
form :Solid
color :White
Safety Information
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Description
Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity. It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells. Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.Related product price
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Suppliers and manufacturers
Henan Tianfu Chemical Co.,Ltd.
Chengdu GLP biotechnology Co Ltd
Chengdu Biopurify Phytochemicals Ltd.
BOC Sciences
Chongqing Chemdad Co., Ltd
Neostar United (Changzhou) Industrial Co., Ltd.
Hubei Ipure Biology Co., Ltd
Hefei TNJ Chemical Industry Co.,Ltd.
