PRL-3 INHIBITOR I
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- ₹0
- Product name: PRL-3 INHIBITOR I
- CAS: 893449-38-2
- MF: C17H11Br2NO2S2
- MW: 485.21
- EINECS:
- MDL Number:MFCD11045303
- Synonyms:PRL-3 INHIBITOR I;Phosphatase of regenerating liver-3, Inhibitor I, 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone;5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone;Phosphatase of regenerating liver-3, Inhibitor I;PRL-3 Inhibitor;PRL-3 Inhibitor - CAS 893449-38-2 - Calbiochem;5-(5-Bromo-2-((2-bromobenzyl)oxy)benzylidene)-2-thioxothiazolidin-4-one;P0180
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Properties
Density :1.85±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: >10mg/mL
form :Yellow solid
pka :7.11±0.50(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
storage temp. :−20°C
solubility :DMSO: >10mg/mL
form :Yellow solid
pka :7.11±0.50(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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Description
Phosphatase of regenerating liver 3 (PRL-3; also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin β1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines.Related product price
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