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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Immunosuppressants >Pimecrolimus

Pimecrolimus

Pimecrolimus Structure
  • ₹13011.65 - ₹52382.18
  • Product name: Pimecrolimus
  • CAS: 137071-32-0
  • MF: C43H68ClNO11
  • MW: 810.45
  • EINECS:603-999-7
  • MDL Number:MFCD00901792
  • Synonyms:ASM 981;SDZ-ASM 981;Picrolimus;Pimecrolimus;15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26as)-;15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-(2-(4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S-(3R*(E(1S*,3S*,4R*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26ar*))-;Unii-7kyv510875;PiMecroliMus(Elidel, SDZ-ASM-981)
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1437
  • Product descriptionPimecrolimus ≥97% (HPLC)
  • Packaging10MG
  • Price₹13011.65
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1437
  • Product descriptionPimecrolimus ≥97% (HPLC)
  • Packaging50MG
  • Price₹52382.18
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1437 Pimecrolimus ≥97% (HPLC) 10MG ₹13011.65 2022-06-14 Buy
Sigma-Aldrich(India) SML1437 Pimecrolimus ≥97% (HPLC) 50MG ₹52382.18 2022-06-14 Buy

Properties

Melting point :135-136 °C
Boiling point :866.1±75.0 °C(Predicted)
Density :1.19
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO (Slightly, Sonicated), Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :9.97±0.70(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P322 Specific measures (see …on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase). Presumably through these actions, it blocks the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) without affecting dendritic cells. Moreover, pimecrolimus suppresses the generation of pro-inflammatory cytokines by T cells, the release of pre-formed inflammatory mediators from mast cells, and the activation of eosinophils. These effects support the use of pimecrolimus in countering inflammatory skin diseases, such as atopic dermatitis (eczema) and psoriasis.

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Suppliers and manufacturers

Shree HariKrishna Pharmaceuticals HRV Global Life Sciences Sumar Biotech LLP Synnat Pharma Pvt Ltd Concord Biotech Limited Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group) Orbit Lifescience Pvt., Ltd. International Drug & Chemical Co. Concord Biotech Limited CONCORD BIOTECH LTD