Pinostrobin
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- ₹0
- Product name: Pinostrobin
- CAS: 480-37-5
- MF: C16H14O4
- MW: 270.28
- EINECS:207-548-1
- MDL Number:MFCD06858342
- Synonyms:2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one;2-Phenyl-5-hydroxy-7-methoxy-2,3-dihydro-4H-1-benzopyran-4-one;Pinostobin;Pistrobin;Pinostrobin,(S)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one;PINOCEMBRIN-7-METHYLETHER(RG)(PLEASE CALL);5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one;5-Hydroxy-7-methoxyflavanone
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Properties
Melting point :100°C
Boiling point :494.9±45.0 °C(Predicted)
Density :1.284±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 12 mg/ml
form :A crystalline solid
pka :7.40±0.40(Predicted)
color :White to yellow
LogP :3.591 (est)
Boiling point :494.9±45.0 °C(Predicted)
Density :1.284±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 12 mg/ml
form :A crystalline solid
pka :7.40±0.40(Predicted)
color :White to yellow
LogP :3.591 (est)
Safety Information
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Description
Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM. Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively). Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).More related product prices
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