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ChemicalBook > Product Catalogue >API >Antipyretic analgesics >Antigout Drugs >Probenecid

Probenecid

Probenecid Structure
  • ₹11030.68 - ₹33665.75
  • Product name: Probenecid
  • CAS: 57-66-9
  • MF: C13H19NO4S
  • MW: 285.36
  • EINECS:200-344-3
  • MDL Number:MFCD00038402
  • Synonyms:4-[(dipropylamino)sulfonyl]-benzoicaci ;Probenecid,98%;NSC 18786;Probenecid (200 mg);4-(DI-N-PROPYLAMINO)SULFONYL BENZOIC ACID 4-[(DIPROPYLAMINO)SULFONYL]BENZOIC ACID AKOS BBS-00002773 LABOTEST-BB LT00772250 P-[DIPROPYLSULFAMOYL]BENZOIC ACID PROBENECID 4-((dipropylaMino)sulfonyl)-benzoicaci 4-(DipropylsulfaMoyl)benzoic acid 4-(dipropylsulfaMoyl)benzoicacid 4-[(dipropylaMino)sulfonyl]-benzoicaci Apurina benacen BeneMid beneMide Benuryl;Soluble probenecid;Probenecid 4-[(Dipropylamino)sulfonyl]benzoic acid;4-(Di-n-propylsulfamoyl)benzoesaeure
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 500MG
  • 25G
  • 100G
  • ManufacturerSigma-Aldrich(India)
  • Product numberP8761
  • Product descriptionProbenecid
  • Packaging100G
  • Price₹33665.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2608
  • Product descriptionProbenecid
  • Packaging500MG
  • Price₹14722
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP8761
  • Product descriptionProbenecid
  • Packaging25G
  • Price₹11030.68
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P8761 Probenecid 100G ₹33665.75 2022-06-14 Buy
Sigma-Aldrich(India) PHR2608 Probenecid 500MG ₹14722 2022-06-14 Buy
Sigma-Aldrich(India) P8761 Probenecid 25G ₹11030.68 2022-06-14 Buy

Properties

Melting point :194-196°C
Boiling point :438.0±47.0 °C(Predicted)
Density :1.2483 (rough estimate)
refractive index :1.6800 (estimate)
storage temp. :Store at RT
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :5.8(at 25℃)
color :White to Off-White
Water Solubility :<0.1 g/100 mL at 20 ºC
Merck :14,7754
Stability :Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference :57-66-9(CAS DataBase Reference)
NIST Chemistry Reference :P-(dipropylsulfamoyl) benzoic acid(57-66-9)
EPA Substance Registry System :Probenecid (57-66-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:

Description

Probenecid is a benzoic acid derivative that inhibits organic anion transporters (OATs) but activates the transient receptor potential (TRP) channel TRPV1. It inhibits OAT1, OAT3, and OAT6 with Ki values of 6.3, 9.0, and 8.4 μM, respectively, as well as OAT2 with an IC50 value of 0.67 μM. It is a poor inhibitor of the organic cation transporters OCT1 and OCT2 (IC50 = 1.6 and 1.7 mM, respectively). Through its effects on OATs, probenecid enhances the renal excretion of urate, alleviating gout, while reducing the elimination of many medications. It also acts as an agonist of TRPV2 (EC50 = 31.9 μM), eliciting nociceptive behavior under inflammatory conditions in mice.

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Suppliers and manufacturers

DK Pharmachem Pvt Ltd ALS INDIA LIFE SCIENCES Maas Pharma Chemicals MEDILUX LABORATORIES PRIVATE LIMITED Jai Radhe Sales Anzen Exports SynZeal Research Pvt Ltd Pharma Affiliates SPB Pharma Chiemimpex International Drug & Chemical Co.