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ChemicalBook > Product Catalogue >API >Respiratory Drugs >Asthma drugs >Pseudoephedrine

Pseudoephedrine

Pseudoephedrine Structure
  • ₹0
  • Product name: Pseudoephedrine
  • CAS: 90-82-4
  • MF: C10H15NO
  • MW: 165.23
  • EINECS:202-018-6
  • MDL Number:MFCD00064256
  • Synonyms:S,S(+)-Pseudoephedrine solution;(+)-pseudoephedrin ;(+)-psi-ephedrin ;(alpha-s)-benzenemethano ;[S-(R*,R*)]-alpha-[1-(methylamino)ethyl]benzenemethanol;2-(Methylamino)-1-phenyl-1-propanol;alpha-(1-(methylamino)ethyl)-,(s-(r*,r*))-benzenemethano ;alpha-[1-(methylamino)ethyl]-,[s-(theta,theta)]-benzenemethano
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :118-120 °C
alpha :52 º (c=0.6, EtOH)
Boiling point :293.09°C (rough estimate)
Density :1.0203 (rough estimate)
vapor pressure :0.016-0.032Pa at 20-25℃
refractive index :1.5200 (estimate)
Flash point :9℃
storage temp. :-20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 5 mg/ml
form :Crystalline
pka :pKa 9.73(H2O,t=25±0.5,I=0.01)(Approximate)
optical activity :[α]20/D +52°, c = 0.6 in ethanol
Water Solubility :<0.5g/L(er)
Merck :13,8007
BRN :2414132
Stability :Stable. Combustible. Incompatible with strong oxidizing agents. May discolour upon exposure to light.
LogP :0.89 at 25℃
CAS DataBase Reference :90-82-4(CAS DataBase Reference)
NIST Chemistry Reference :Pseudoephedrine, (+)-(90-82-4)
EPA Substance Registry System :Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, (.alpha.S)- (90-82-4)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Pseudoephedrine is a stereoisomer of ephedrine, in the drug class of sympathomimetics. It occurs naturally in plants of the genus Ephedra. Pseudoephedrine is a mixed-acting decongestant, which activates α- and β-adrenergic receptors directly by binding to the receptor itself, and indirectly by causing norepinephrine release in synaptic nerve terminals.
Pseudoephedrine is also used illicitly in the production of methamphetamine. In the United States, two recent acts of legislation – the Combat Methamphetamine Epidemic Act of 2005 and the Methamphetamine Production Prevention Act of 2008– have created stringent regulation on the sale of pseudoephedrine without a prescription. Pseudoephedrine-containing products were moved behind the counter, only to be sold by the pharmacist using their professional judgment and discretion. Limitations on the quantity of pseudoephedrine that could be purchased at one time and over a period of timewere enacted, and strict record keeping was required.

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