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(R,S)-ANATABINE

(R,S)-ANATABINE Structure
  • ₹51635.25
  • Product name: (R,S)-ANATABINE
  • CAS: 2743-90-0
  • MF: C10H12N2
  • MW: 160.22
  • EINECS:
  • MDL Number:MFCD00078278
  • Synonyms:(R,S)-ANATABINE;ANATABINE, (+/-)-(RG);(+/-)-Anatabine, 3-(1,2,3,6-Tetrahydropyridin-2-yl)pyridine, 2-(Pyridin-3-yl)-1,2,3,6-tetrahydropyridine;Anatabine, froM Nicotiana tabacuM L.;D,L-ANATABINE;1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE;Anatabine, 97%, from Nicotiana tabacum L.;1,2,3,6-Tetrahydro-2,3'-bipyridine 98%
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR3060
  • Product descriptionNicotine Related Compound A/EP Impurity A pharmaceutical secondary standard, certified reference material
  • Packaging50MG
  • Price₹51635.25
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PHR3060 Nicotine Related Compound A/EP Impurity A pharmaceutical secondary standard, certified reference material 50MG ₹51635.25 2022-06-14 Buy

Properties

Boiling point :136
Density :1.045±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, Refrigerator, Under Inert Atmosphere
solubility :≤15mg/ml in DMSO;15mg/ml in dimethyl formamide
form :solution in ethanol.
pka :8.84±0.40(Predicted)
color :Light yellow to yellow
Stability :Hygroscopic, Light Sensitive
CAS DataBase Reference :2743-90-0

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

?(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of ?(R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. ?(R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, ?(R,S)-anatabine diminishes amyloid beta (Aβ) production in vitro and in vivo. ?(R,S)-Anatabine reduces (600 μg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ1-40 and Aβ1-42 in a dose dependent manner in SHSY-5Y cells. ?(R,S)-Anatabine also dose dependently inhibits NF-κB activation.

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