Roflumilast
- ₹7079.55 - ₹28740.38
- Product name: Roflumilast
- CAS: 162401-32-3
- MF: C17H14Cl2F2N2O3
- MW: 403.21
- EINECS:685-382-2
- MDL Number:MFCD00938270
- Synonyms:ROFLUMILAST;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;B 9302-107;BY 217;BYK 20869;Daxas;Roflumilast / 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide;3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
4 prices
Selected condition:
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- 250MG
- 1G
- ManufacturerTCI Chemicals (India)
- Product numberR0193
- Product descriptionRoflumilast
- Packaging250MG
- Price₹9700
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberR0193
- Product descriptionRoflumilast
- Packaging1G
- Price₹19100
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1099
- Product descriptionRoflumilast ≥98% (HPLC)
- Packaging10MG
- Price₹7079.55
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1099
- Product descriptionRoflumilast ≥98% (HPLC)
- Packaging50MG
- Price₹28740.38
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
TCI Chemicals (India) | R0193 | Roflumilast | 250MG | ₹9700 | 2022-05-26 | Buy |
TCI Chemicals (India) | R0193 | Roflumilast | 1G | ₹19100 | 2022-05-26 | Buy |
Sigma-Aldrich(India) | SML1099 | Roflumilast ≥98% (HPLC) | 10MG | ₹7079.55 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1099 | Roflumilast ≥98% (HPLC) | 50MG | ₹28740.38 | 2022-06-14 | Buy |
Properties
Melting point :158°C
Boiling point :430.6±45.0 °C(Predicted)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
pka :9.89±0.70(Predicted)
form :powder
color :white to beige
Merck :14,8249
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey :MNDBXUUTURYVHR-UHFFFAOYSA-N
SMILES :C(NC1C(Cl)=CN=CC=1Cl)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference :162401-32-3(CAS DataBase Reference)
Boiling point :430.6±45.0 °C(Predicted)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
pka :9.89±0.70(Predicted)
form :powder
color :white to beige
Merck :14,8249
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey :MNDBXUUTURYVHR-UHFFFAOYSA-N
SMILES :C(NC1C(Cl)=CN=CC=1Cl)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference :162401-32-3(CAS DataBase Reference)
Safety Information
Symbol(GHS): | |||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||||||||||||||||||
Hazard statements: |
|
||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
Type 4 cyclic nucleotide phosphodiesterase (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50 = < 1 nM for both human PDE4B and PDE4D). It is selective for PDE4, with IC50 values against other PDE forms being greater than 10 μM. Roflumilast demonstrates good bioavailability and has applications in respiratory diseases, including asthma and chronic obstructive pulmonary disease.More related product prices
2-Chloro-5-chloromethylpyridine Fleroxacin Clopyralid Benzamide p-Aminobenzamide Ezetimibe 162401-62-9 benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- 22889-78-7 RofluMilast related substance RofluMilast related substance RofluMilast N-Oxide N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- RofluMilast related substance N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMideRelated product price
- Poly(tetrafluoroethylene)
₹2637-31164 - 2-Chloro-5-chloromethylpyridine
₹2600-10034.78 - Fleroxacin
₹9700-36047.25