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ChemicalBook > Product Catalogue >Chemical Reagents >Organic reagents >aliphatic ketones >(S)-(+)-Ketoprofen

(S)-(+)-Ketoprofen

(S)-(+)-Ketoprofen Structure
  • ₹10900.78
  • Product name: (S)-(+)-Ketoprofen
  • CAS: 22161-81-5
  • MF: C16H14O3
  • MW: 254.28
  • EINECS:606-944-5
  • MDL Number:MFCD00673316
  • Synonyms:(+)-hydratropicaci ;(S)-(+)-KETOPROFEN;(S)-(+)-3-BENZOYL-ALPHA-METHYLBENZENE-ACETIC ACID;[S]-2-[3-BENZOYLPHENYL]PROPIONIC ACID;3-(1-Hydrocarboxyethyl)benzophenone;Dexktoprofen;(S)-(+)-3-Benzoyl-α-methylbenzeneacetic acid, (S)-2-(3-Benzoylphenyl)propionic acid;(S)-2-(3-Benzoylphenyl)propanoic acid
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product number471909
  • Product description(S)-(+)-Ketoprofen 99%
  • Packaging1G
  • Price₹10900.78
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 471909 (S)-(+)-Ketoprofen 99% 1G ₹10900.78 2022-06-14 Buy

Properties

Melting point :75-78 °C(lit.)
Boiling point :431.3±28.0 °C(Predicted)
Density :1.198±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :insoluble in H2O; ≥10.6 mg/mL in DMSO; ≥20.55 mg/mL in EtOH
form :White solid.
pka :4.23±0.10(Predicted)
color :White to off-white
optical activity :[α]22/D +49°, c = 1 in methanol
CAS DataBase Reference :22161-81-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ketoprofen is a non-selective, non-steroidal, anti-inflammatory drug exhibiting IC50 values of 0.5 and 2.33 μM for human recombinant COX-1 and COX-2 , respectively. Ketoprofen is commonly used in vivo as a racemic mixture of (R)- and (S)-enantiomers. (S)-Ketoprofen is a potent inhibitor of COX-1 and COX-2 (IC50s = 1.9 and 27 nM, respectively), whereas the (R)-enantiomer is 100 to 1,000 times less potent. Notably, (S)-ketoprofen is known to be formed from the (R)-enantiomer in several animal species, except in humans and guinea pigs. Also, the pharmacokinetics of ketoprofen enantiomers and their glucuronide metabolites are altered in humans with rheumatoid arthritis or renal disease.

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Suppliers and manufacturers

Henan Bao Enluo International TradeCo.，LTD
(S)-(+)-Ketoprofen
₹100.00 /1kg
(S)-(+)-Ketoprofen CAS:22161-81-5
BEC Chemicals Pvt Ltd PANCHSHEEL ORGANICS LTD A.J Chemicals CLEARSYNTH LABS LTD. SynZeal Research Pvt Ltd Pharma Affiliates Pharmaffiliates Analytics and Synthetics P. Ltd
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED