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SB 203580 (hydrochloride)

SB 203580 (hydrochloride) Structure
  • ₹15760 - ₹42220
  • Product name: SB 203580 (hydrochloride)
  • CAS: 869185-85-3
  • MF: C21H17ClFN3OS
  • MW: 413.9
  • EINECS:
  • MDL Number:MFCD01862622
  • Synonyms:RWJ 64809 hydrochloride;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product number559395
  • Product descriptionSB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kina
  • Packaging1MG
  • Price₹15760
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number559395
  • Product descriptionSB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kina
  • Packaging10MG
  • Price₹42220
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 559395 SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kina 1MG ₹15760 2022-06-14 Buy
Sigma-Aldrich(India) 559395 SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kina 10MG ₹42220 2022-06-14 Buy

Properties

storage temp. :-20C
solubility :insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO
form :Bright yellow solid
color :Light yellow to yellow
Water Solubility :Soluble to 25 mM in water
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Mitogen-activated protein kinases (MAPKs) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. p38 MAPK activity in heat-shocked HeLa cells and osmotically stressed PC12 cells is inhibited by SB 203580 with an IC50 value of 0.6 μM. SB 203580 also prevents the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1) at IC50 values of 3-5 μM. SB 203580 (hydrochloride) has a formulation with greater solubility in organic solvents than standard SB 203580 .

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