SUFUGOLIX
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- ₹0
- Product name: SUFUGOLIX
- CAS: 308831-61-0
- MF: C36H31F2N5O4S
- MW: 667.72
- EINECS:
- MDL Number:MFCD09837896
- Synonyms:SUFUGOLIX;TAK013;N-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea;TAK013;TAK 013;Sufugolix(TAK-013);SUFUGOLIX, >98%;tak-013, >98%;Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[methyl(phenylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Density :1.383±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C,unstable in solution, ready to use.
solubility :DMF: 5mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 3mg/mL
form :A solid
pka :13.20±0.70(Predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C,unstable in solution, ready to use.
solubility :DMF: 5mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 3mg/mL
form :A solid
pka :13.20±0.70(Predicted)
color :Light yellow to yellow
Safety Information
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Description
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM). Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM). Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.Related product price
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