Sanggenon C
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- Product name: Sanggenon C
- CAS: 80651-76-9
- MF: C40H36O12
- MW: 708.71
- EINECS:
- MDL Number:MFCD32004761
- Synonyms:sanggenone;Sanggenon C;(5aR,10aS)-2-[6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one;2-[(1S)-6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10aβ-tetrahydroxy-5aβ-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one;Sanggenone C;(5aR,10aS)-2-[(1S,5S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-11H-benzofuro[3,2-b][1]benzopyran-11-one;11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-, (5aR,10aS)-;(5aR,10aS)-2-((1S,2R,3S)-2-(2,4-Dihydroxybenzoyl)-2',4'-dihydroxy-5-methyl-1,2,3,6-tetrahydro-[1,1'-biphenyl]-3-yl)-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-en-1-yl)-5a,10a-dihydro-11H-benzofuro[3,2-b]chromen-11-one
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Properties
Melting point :> 240°C (dec.)
Boiling point :995.5±65.0 °C(Predicted)
Density :1.512
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Acetone (Slightly), Methanol (Slightly)
pka :6.61±0.60(Predicted)
form :Solid
color :Yellow
Boiling point :995.5±65.0 °C(Predicted)
Density :1.512
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Acetone (Slightly), Methanol (Slightly)
pka :6.61±0.60(Predicted)
form :Solid
color :Yellow
Safety Information
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Description
Sanggenone C is a flavonoid that has been found in mulberry bark and has diverse biological activities. It inhibits TNF-α- or IL-1β-induced polymorphonuclear leukocyte (PMN) adhesion to human synovial cells (HSCs; IC50s = 27.29 and 54.43 nM, respectively), as well as inhibits NF-κB activation in HSCs. Sanggenone C induces apoptosis and production of reactive oxygen species (ROS) in HT-29 cells when used at concentrations ranging from 10 to 40 μM. It decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model when administered at a dose of 10 mg/kg. Sanggenone C increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis. It also attenuates cardiac hypertrophy and fibrosis and reduces activation of nuclear factor of activated T cells 2 (NFAT2) in a mouse model of pressure overload-induced cardiac hypertrophy.Related product price
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Suppliers and manufacturers
Chengdu Greenpure Biopharma CO.,Ltd
Chengdu GLP biotechnology Co Ltd
Chengdu Biopurify Phytochemicals Ltd.
CONIER CHEM AND PHARMA LIMITED
ANHUI WITOP BIOTECH CO., LTD
Dayang Chem (Hangzhou) Co.,Ltd.
Hefei TNJ Chemical Industry Co.,Ltd.
