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ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Heterocyclic compound >Pyran compounds >7,8-Dihydroxycoumarin

7,8-Dihydroxycoumarin

7,8-Dihydroxycoumarin Structure
  • ₹7902 - ₹36783.35
  • Product name: 7,8-Dihydroxycoumarin
  • CAS: 486-35-1
  • MF: C9H6O4
  • MW: 178.14
  • EINECS:207-632-8
  • MDL Number:MFCD00016977
  • Synonyms:7,8-DIHYDROXY-2H-1-BENZOPYRAN-2-ONE;7,8-DIHYDROXY-CHROMEN-2-ONE;7,8-DIHYDROXYCOUMARIN;AKOS 213-37;7,8-dihydroxy-2h-1-benzopyran-2-on ;7,8-dihydroxy-coumari ;DAPHNETIN;7,8-Diydroxycoumarin
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 5MG
  • 25MG
  • 1G
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberD4001
  • Product descriptionDaphnetin
  • Packaging1G
  • Price₹15000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD4001
  • Product descriptionDaphnetin
  • Packaging5G
  • Price₹34800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD5564
  • Product description7,8-Dihydroxycoumarin ≥97%, powder
  • Packaging5MG
  • Price₹8714.13
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD5564
  • Product description7,8-Dihydroxycoumarin ≥97%, powder
  • Packaging25MG
  • Price₹36783.35
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number D 0355
  • Product descriptionDaphnetin+ 97%
  • Packaging5mg
  • Price₹7902
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number D 0355
  • Product descriptionDaphnetin+ 97%
  • Packaging25mg
  • Price₹33603
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) D4001 Daphnetin 1G ₹15000 2022-05-26 Buy
TCI Chemicals (India) D4001 Daphnetin 5G ₹34800 2022-05-26 Buy
Sigma-Aldrich(India) D5564 7,8-Dihydroxycoumarin ≥97%, powder 5MG ₹8714.13 2022-06-14 Buy
Sigma-Aldrich(India) D5564 7,8-Dihydroxycoumarin ≥97%, powder 25MG ₹36783.35 2022-06-14 Buy
ottokemi D 0355 Daphnetin+ 97% 5mg ₹7902 2022-05-26 Buy
ottokemi D 0355 Daphnetin+ 97% 25mg ₹33603 2022-05-26 Buy

Properties

Melting point :265-268°C (dec.)
Boiling point :270.35°C (rough estimate)
Density :1.3431 (rough estimate)
refractive index :1.4500 (estimate)
storage temp. :room temp
solubility :soluble in Methanol
form :solid
pka :7.61±0.20(Predicted)
color :White to Light yellow to Light red
Merck :14,2817
InChI :InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
InChIKey :ATEFPOUAMCWAQS-UHFFFAOYSA-N
SMILES :C1(=O)OC2=C(O)C(O)=CC=C2C=C1
LogP :0.884 (est)
CAS DataBase Reference :486-35-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. Inhibits EGFR kinase (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25 μM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.

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Suppliers and manufacturers

GLR Innovations SynthoCascade Research Laboratories chakrachem Lifesciences Orgachem Laboratories Vyas Bio Life Sciences Pvt. Ltd Orgachem Laboratories Oceanic Pharmachem Pvt. Ltd. CHEMSWORTH A.J Chemicals TCI Chemicals (India) Pvt. Ltd.